HLA-B*15:04:04 differs from HLA-B*15:04:01 by one nucleotide at codon 238 (gat > gac).
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Targeted insertion of heterogenous DNA using Cas9-gRNA ribonucleoprotein-mediated gene editing in .
Bioengineered
December 2025
Department of BioMedical Bigdata (BK21) and Research Institute of Life Sciences, Gyeongsang National University, Jinju, Republic of Korea.
Gene editing is emerging as a powerful tool for introducing novel functionalities in mushrooms. While CRISPR/Cas9-induced double-strand breaks (DSBs) typically rely on non-homologous end joining (NHEJ) for gene disruption, precise insertion of heterologous DNA in mushrooms is less explored. Here, we evaluated the efficacy of inserting donor DNAs (8-1008 bp) with or without homologous arms at Cas9-gRNA RNP-induced DSBs.
View Article and Find Full Text PDFImpact of dairy calf management practices on the intestinal tract microbiome pre-weaning.
J Med Microbiol
January 2025
Animal and Agriculture Department, Hartpury University, Gloucester, GL19 3BE, UK.
Microbiota in the gastrointestinal tract (GIT) consisting of the rumen and hindgut (the small intestine, cecum and colon) in dairy calves play a vital role in their growth and development. This review discusses the development of dairy calf intestinal microbiomes with an emphasis on the impact that husbandry and rearing management have on microbiome development, health and growth of pre-weaned dairy calves. The diversity and composition of the microbes that colonize the lower GIT (small and large intestine) can have a significant impact on the growth and development of the calf, through influence on nutrient metabolism, immune modulation, resistance or susceptibility to infection, production outputs and behaviour modification in adult life.
View Article and Find Full Text PDFDeep Thermalization in Gaussian Continuous-Variable Quantum Systems.
Phys Rev Lett
December 2024
National University of Singapore, Department of Physics, Singapore 117551.
We uncover emergent universality arising in the equilibration dynamics of multimode continuous-variable systems. Specifically, we study the ensemble of pure states supported on a small subsystem of a few modes, generated by Gaussian measurements on the remaining modes of a globally pure bosonic Gaussian state. We find that beginning from highly entangled, complex global states, such as random Gaussian states and product squeezed states coupled via a deep array of linear optical elements, the induced ensemble attains a universal form, independent of the choice of measurement basis: it is composed of unsqueezed coherent states whose displacements are distributed normally and isotropically, with variance depending on only the particle-number density of the system.
View Article and Find Full Text PDFDefect Conformal Field Theory from Sachdev-Ye-Kitaev Interactions.
Phys Rev Lett
December 2024
Tulane University, Department of Physics and Engineering Physics, New Orleans, Louisiana 70118, USA.
The coupling between defects and extended critical degrees of freedom gives rise to the intriguing theory known as defect conformal field theory (CFT). In this work, we introduce a novel family of boundary and interface CFTs by coupling N Majorana chains with SYK_{q} interactions at the defect. Our analysis reveals that the interaction with q=2 constitutes a new marginal defect.
View Article and Find Full Text PDFMachine-Learning Modeling of Elemental Ferroelectric Bismuth Monolayer.
Phys Rev Lett
December 2024
Xi'an Jiaotong University, School of Microelectronics & State Key Laboratory for Mechanical Behavior of Materials, Xi'an 710049, China.
The bismuth monolayer has recently been experimentally identified as a novel platform for the investigation of two-dimensional single-element ferroelectric system. Here, we model the potential energy surface of a bismuth monolayer by employing a message-passing neural network and achieve an error smaller than 1.2 meV per atom.
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