AI Article Synopsis
- Staphylococcus aureus bacteremia (SAB) mainly consists of monomicrobial infections, with polymicrobial cases (P-SAB) being relatively rare, observed in 6.1% of cases.
- P-SAB is significantly more common in necrotizing soft tissue infections and certain medical device-related infections compared to simple cellulitis/abscesses and other sites.
- Patients with P-SAB have a higher mortality rate (50.5%) compared to those with monomicrobial SAB (24.2%), indicating that P-SAB is a more severe condition that needs further investigation.
Article Abstract
Staphylococcus aureus bacteremia (SAB) is usually monomicrobial (M-SAB). We reviewed SAB in adults (≥18years old) over a 13year-period and compared polymicrobial (P-SAB) and M-SAB. We encountered 93 P-SAB among 1537 SAB cases (6.1%). The source distribution was comparable; however, source-specified differences were apparent. P-SAB was noted in 12/58 (20.7%) necrotizing soft tissue infections/sacral decubiti and foot gangrene vs. 1/122 (0.8%) cellulitis/abscesses (P<0.001), in 7/64 (10.9%) femoral intravascular catheters (IVC) vs.16/376 (4.3%) IVC in other sites (P=0.03) and 15/134 (11.2%) healthcare-associated pneumonia (HAP) vs. 1/33 (3.0%) community-associated cases (P=0.1). Methicillin-resistance frequency was similar but community-associated SCCmec types (IV/V) were infrequent (17.9% vs. 34.2%; P=0.04). P-SAB was associated with higher mortality (50.5% vs. 24.2%; P<0.001) across nearly all sources. In summary, P-SAB is infrequent, usually encountered in necrotizing soft tissue infections/decubiti, femoral IVC and possibly HAP. The actual incidence of S. aureus in these infections should be defined.
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| http://dx.doi.org/10.1016/j.diagmicrobio.2016.08.010 | DOI Listing |
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