AI Article Synopsis
- Mammary analogue secretory carcinoma (MASC) is a newly identified type of salivary gland tumor that resembles secretory carcinoma of the breast in both appearance and genetic makeup (specifically the ETV6 gene rearrangement).
- Prior to being formally recognized, MASC was often misclassified as other types of tumors such as acinic cell carcinoma and unspecified adenocarcinoma.
- Diagnosing MASC can be challenging due to its similarities with other salivary gland tumors, but a definitive diagnosis can be made through certain genetic tests, particularly looking for the ETV6-NTRK3 gene fusion, though its long-term prognosis is still uncertain.
Article Abstract
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that shares the same histologic appearance and ETV6 gene (12p13) rearrangement as secretory carcinoma of the breast. Prior to its recognition, MASC cases were commonly labeled acinic cell carcinoma and adenocarcinoma, not otherwise specified. Despite distinctive histologic features, MASC may be difficult to distinguish from other salivary gland tumors, in particular zymogen-poor acinic cell carcinoma and low-grade salivary duct carcinoma. Although characteristic morphologic and immunohistochemical features form the basis of a diagnosis of MASC, the presence of an ETV6-NTRK3 gene fusion is confirmatory. Given its recent recognition the true prognostic import of MASC is not yet clearly defined.
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| http://dx.doi.org/10.5858/arpa.2015-0075-RS | DOI Listing |
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