The tribology of an open system at temperatures ranging between 3 °C and -35 °C, with and without snow, was investigated using a pin-on-disc tribometer mounted in a temperature-controlled environmental chamber. The relationship between the microstructure and ductility of the materials and the tribology at the contacting surfaces was investigated. The study shows that during continuous sliding, pressure causes snow particles to melt into a liquid-like layer, encouraging the generation of oxide flakes on the contact path. The friction coefficient and wear rate are dramatically reduced through an oxidative friction and wear mechanism. In the absence of snow, the tribological process is controlled by the low temperature brittleness of steel in the temperature range from 3 °C to -15 °C. At these temperatures, cracks are prone to form and extend on the worn surfaces, resulting in the spalling of bulk scraps, which are crushed into debris that increases the friction coefficient and wear rate due to strong abrasion. When the temperature falls to -25 °C, an ice layer condenses on the metal surfaces and relaxes the tribological process in the same way as the added snow particles, which significantly decreases the friction and wear.
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http://dx.doi.org/10.1038/srep32455 | DOI Listing |
JMIR Hum Factors
January 2025
Institute of General Practice, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Background: The internet is a key source of health information, but the quality of content from popular search engines varies, posing challenges for users-especially those with low health or digital health literacy. To address this, the "tala-med" search engine was developed in 2020 to provide access to high-quality, evidence-based content. It prioritizes German health websites based on trustworthiness, recency, user-friendliness, and comprehensibility, offering category-based filters while ensuring privacy by avoiding data collection and advertisements.
View Article and Find Full Text PDFCan J Microbiol
January 2025
McGill University, Department of Earth and Planetary Sciences, Montreal, Quebec, Canada;
Climate change is rapidly altering Arctic marine environments, leading to warmer waters, increased river discharge, and accelerated sea ice melt. The Hudson Bay Marine System (HBMS) experiences the fastest rate of sea ice loss in the Canadian North resulting in a prolonged open water season during the summer months. We examined microbial communities in the Hudson Strait using high throughput 16s rRNA gene sequencing during the peak of summer, in which the bay was almost completely ice-free, and air temperatures were high.
View Article and Find Full Text PDFMol Biol Evol
January 2025
Center for Genomics and Systems Biology, Department of Biology, New York University.
Copy-number variants (CNVs) are an important class of genetic variation that can mediate rapid adaptive evolution. Whereas CNVs can increase the relative fitness of the organism, they can also incur a cost due to the associated increased gene expression and repetitive DNA. We previously evolved populations of Saccharomyces cerevisiae over hundreds of generations in glutamine-limited (Gln-) chemostats and observed the recurrent evolution of CNVs at the GAP1 locus.
View Article and Find Full Text PDFJ Am Med Inform Assoc
January 2025
South London and Maudsley NHS Foundation Trust, London SE5 8AZ, United Kingdom.
Objective: A proof-of-concept study aimed at designing and implementing Visual & Interactive Engagement With Electronic Records (VIEWER), a versatile toolkit for visual analytics of clinical data, and systematically evaluating its effectiveness across various clinical applications while gathering feedback for iterative improvements.
Materials And Methods: VIEWER is an open-source and extensible toolkit that employs natural language processing and interactive visualization techniques to facilitate the rapid design, development, and deployment of clinical information retrieval, analysis, and visualization at the point of care. Through an iterative and collaborative participatory design approach, VIEWER was designed and implemented in one of the United Kingdom's largest National Health Services mental health Trusts, where its clinical utility and effectiveness were assessed using both quantitative and qualitative methods.
Neuro Oncol
January 2025
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Background: Central nervous system (CNS) tumors lead to cancer-related mortality in children. Genetic ancestry-associated cancer prevalence and outcomes have been studied, but is limited.
Methods: We performed genetic ancestry prediction in 1,452 pediatric patients with paired normal and tumor whole genome sequencing from the Open Pediatric Cancer (OpenPedCan) project to evaluate the influence of reported race and ethnicity and ancestry-based genetic superpopulations on tumor histology, molecular subtype, survival, and treatment.
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