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Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites. | LitMetric
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Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites.

Tomasz A Leski Michael G Stockelman Umaru Bangura Daniel Chae Rashid Ansumana David A Stenger Gary J Vora Chris R Taitt

Antimicrob Agents Chemother

Center for Bio/Medical Science and Engineering, Naval Research Laboratory, Washington, DC, USA.

Published: November 2016

A collection of 74 Enterobacteriaceae isolates found in Bo, Sierra Leone, were tested for quinolone antibiotic susceptibility and resistance mechanisms. The majority of isolates (62%) were resistant to quinolones, and 61% harbored chromosomal gyrA and/or parC mutations. Plasmid-mediated quinolone resistance genes were ubiquitous, with qnrB and aac(6')-Ib-cr being the most prevalent. Mutated LexA binding sites were found in all qnrB1 genes, and truncated qnrB pseudogenes were found in the majority of Citrobacter isolates.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075108PMC
http://dx.doi.org/10.1128/AAC.01576-16DOI Listing

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