AI Article Synopsis
- The Wnt signaling pathway is crucial for the development and maintenance of blood and immune cells, but its specific functions are still being debated in research.
- Leukemic stem cells exploit the Wnt pathway to enhance their self-renewal and growth, diverging from normal blood cell behavior.
- The review explores how improper Wnt signaling can lead to leukemia through both direct effects on the cells and indirect effects influenced by the surrounding microenvironment.
Article Abstract
The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for their self-renewal and proliferation. Here we review the multiple ways dysregulated Wnt signaling can contribute to leukemogenesis, both cell autonomously as well as by changes in the microenvironment.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040980 | PMC |
| http://dx.doi.org/10.3390/cancers8090078 | DOI Listing |
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