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A chemical derivatization-based pseudotargeted liquid chromatography-tandem mass spectrometry method for sensitive and high coverage determination of bile acids in human serum.
Anal Chim Acta
January 2024
Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China; Therapeutic Drug Monitoring and Clinical Toxicology Center of Peking University, Beijing, 100191, China. Electronic address:
Global profiling of bile acids (BAs) is imperative for understand their function and disease pathogenesis. But it is still a challenging task, as the collision-induced dissociation (CID) fragment ions of unconjugated BAs showed low ion intensities to insufficient analysis. Herein, we developed a highly sensitive method for pseudotargeted profiling of BAs by chemical derivatization.
View Article and Find Full Text PDFCharacterization of Metabolic Correlations of Ursodeoxycholic Acid with Other Bile Acid Species through In Vitro Sequential Metabolism and Isomer-Focused Identification.
Molecules
June 2023
Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
As a first-line agent for cholestasis treatment in a clinic, ursodeoxycholic acid rectifies the perturbed bile acids (BAs) submetabolome in a holistic manner. Considering the endogenous distribution of ursodeoxycholic acid and extensive occurrences of isomeric metabolites, it is challenging to point out whether a given bile acid species is impacted by ursodeoxycholic acid in a direct or indirect manner, thus hindering the therapeutic mechanism clarification. Here, an in-depth exploration of the metabolism pattern of ursodeoxycholic acid was attempted.
View Article and Find Full Text PDFConcurrence of Guillain-Barré syndrome and primary biliary cholangitis not related to SARS-CoV-2: Case report.
Medwave
April 2023
Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
Introduction: Guillain-Barré syndrome is a polyradiculoneuropathy of autoimmune origin, considered the most frequent cause of acute flaccid paralysis. Various associations of Guillain-Barré syndrome with other non-neurological autoimmune diseases have been reported, some of them extremely rare, such as that which occurs with primary biliary cholangitis, a chronic disease of autoimmune etiology whose diagnosis is also supported by the clinical picture. , in the alteration of liver enzymes and the presence of anti-mitochondrial antibodies.
View Article and Find Full Text PDFWe present the case of a 64-year-old male with a history of chronic liver disease due to hepatitis C virus, with a sustained viral response after oral antiviral treatment and without follow-up for 5 years. He was admitted after a one-month history of constitutional symptoms, low-grade fever, abdominal pain and a palpable epigastric tumor. Analysis showed marked elevation of acute phase reactants (48,000 leukocytes and C-reactive protein of 19mg/dl) and dissociated cholestasis.
View Article and Find Full Text PDFThe protective effect of boric acid on cholestatic rat liver ischemia reperfusion injury.
Turk J Med Sci
October 2021
Department of General Surgery, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Turkey.
Article Synopsis
- - The study investigated the protective effects of boric acid (BA) on liver injury caused by ischemia-reperfusion (IR) after biliary blockage in female rats, comparing a control group, an IR group, and a BA-treated IR group.
- - Results showed that both IR groups experienced higher liver enzyme levels and lower albumin levels compared to the control, but the BA+IR group exhibited better antioxidant status and less total oxidant status.
- - Histopathological analysis revealed significant liver damage in the IR group, while the BA+IR group showed less severe inflammation and cellular damage, suggesting BA's potential as a protective agent in cholestatic liver injury.
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