Purpose: To determine when patients recover the ability to safely operate the brakes of an automobile after a right-knee anterior cruciate ligament reconstruction (ACLR).
Methods: A computerized driving simulator was used to determine braking ability after an isolated right-knee ACLR. Thirty healthy volunteers were tested at 1 visit to determine normal mean values, and 27 treatment subjects were tested at 1 week, 3 weeks, and 6 weeks after ACLR. Nine study subjects were treated with a patella tendon (BPTB) autograft, 9 were treated with a hamstring (HS) autograft, and 9 were treated with a tibialis anterior (TA) allograft. The driving simulator collected data on brake reaction time (BRT), brake travel time (BTT), and total brake time (TBT) at each visit.
Results: The control group generated a BRT of 725 milliseconds, BTT of 2.87 seconds, and TBT of 3.59 seconds. At week 1, all treatment patients had significant differences compared with controls for BRT, BTT, and TBT, except the BTT of the HS group. At week 3, all measures for the allograft group and the BRT for both autograft groups were no longer significantly different compared with controls, but significant differences were found for TBT in the HS and BPTB groups (P = .03, P = .01). At week 6, BRT, BTT, and TBT were no longer significantly different for either the HS group or BPTB group.
Conclusions: Patients who underwent a right-knee ACLR with a TA allograft regained normal braking times by week 3 postoperatively. In contrast, those treated with a BPTB or HS autograft demonstrated significantly delayed braking times at 3 weeks but returned to normal braking ability by week 6. Those treated with an autograft had an earlier return of normalized BRT than BTT.
Level Of Evidence: Level III, case-control series.
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http://dx.doi.org/10.1016/j.arthro.2016.05.043 | DOI Listing |
Alzheimers Dement
December 2024
University of Kansas Medical Center, Kansas City, KS, USA.
Background: Evidence in adults without Down syndrome (DS) suggests that exercise during mid-life improves cognitive function and decreases risk of later life dementia. Studies supporting this relationship in adults with DS are limited. The purpose of this study was to examine changes in cognitive function after a 12-mo exercise intervention in adults with DS without dementia.
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December 2024
University of Toronto, Toronto, ON, Canada.
Background: Driving cessation among people with cognitive impairments (e.g., Mild Cognitive Impairment; MCI) significantly impacts their independence and overall well-being.
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December 2024
University of Alabama in Huntsville, Huntsville, AL, USA.
Currently, there are no curative treatments for Alzheimer's Disease. It is crucial to develop screening tools that detect early signs of decline, allowing for timely interventions that may impede the progression of cognitive impairment. Neurospective is a mobile application platform designed to facilitate the early detection of cognitive decline, including mild cognitive impairment (MCI) and pre-clinical Alzheimer's disease and related dementias (ADRD).
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January 2025
Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
Background And Aim: As a classical formula to invigorate blood circulation, Huoxue Tongluo Qiwei Decoction (HTQD) can effectively treat hypertensive erectile dysfunction (ED), but its exact mechanism of action is not yet clear. The goal of this research was to explore the potential mechanism of HTQD in improving hypertensive erectile dysfunction in rats through transcriptomics, network pharmacology, and associated animal experimentations.
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Environ Sci Technol
January 2025
College of Natural Resources and Environment, Northwest A&F University, Yangling 712100, China.
Interactions between manganese dioxides (MnO) and dissolved organic matter (DOM) have long been the subject of scientific inquiry. However, the effect of MnO crystallinity on the DOM fate remains unclear. Herein, we comprehensively investigate the adsorption, protection, and mineralization of DOM by MnO with various crystallinities (order of crystallinity: γ-30 < γ-90 < γ-120).
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