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Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution. | LitMetric

Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution.

Structure

Infection and Immunity Program, The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia. Electronic address:

Published: October 2016

AI Article Synopsis

Article Abstract

In HLA-DQ8-associated celiac disease, TRAV26-2-TRBV9 and TRAV8-3-TRBV6 T cells recognize the immunodominant DQ8-glia-α1 epitope, whereupon a non-germline-encoded arginine residue played a key role in binding HLA-DQ8-glia-α1. Whether distinct T cell receptor (TCR) recognition modes exist for gliadin epitopes remains unclear. TCR repertoire analysis revealed populations of HLA-DQ8-glia-α1 and HLA-DQ8.5-glia-γ1 restricted TRAV20-TRBV9 T cells that did not possess a non-germline-encoded arginine residue. The crystal structures of a TRAV20-TRBV9 TCR-HLA-DQ8-glia-α1 complex and two TRAV20-TRBV9 TCR-HLA-DQ8.5-glia-γ1 complexes were determined. This revealed that the differential specificity toward DQ8-glia-α1 and DQ8.5-glia-γ1 was governed by CDR3β-loop-mediated interactions. Surprisingly, a germline-encoded arginine residue within the CDR1α loop of the TRAV20 TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2-TRBV9 and TRAV8-3-TRBV6 TCRs. Thus, in celiac disease, the responding TCR repertoire is driven by a common mechanism that selects for structural elements within the TCR that have convergent binding solutions in HLA-DQ8-gliadin recognition.

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Source
http://dx.doi.org/10.1016/j.str.2016.07.010DOI Listing

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