AI Article Synopsis
- The study examined how antibiotic prophylaxis affects the presence of certain antibiotic-resistant bacteria (ESBL/AmpC/CPE) in patients undergoing elective surgeries.
- Patients from Surgical Gastroenterology and Orthopedic Surgery provided fecal samples before and after procedures, revealing stable carriage rates of ESBL/AmpC producers, with no CPE found.
- The most common bacteria identified were Escherichia coli, with specific ESBL types being prevalent, and the antibiotic regimens used showed no significant effect on bacterial carriage rates; however, prior hospitalization and antibiotic use were linked to higher carriage in Surgical Gastroenterology patients.
Article Abstract
The impact of antibiotic prophylaxis on fecal carriage of ESBL-/AmpC-/carbapenemase-producing Enterobacteriaceae (CPE) was investigated. Patients admitted for elective surgery or diagnostic procedure in a Department of Surgical Gastroenterology (SG) (n= 450) and Orthopedic Surgery (OS) (n= 300) provided a fecal swab at admission and responded to a questionnaire on possible exposures. SG patients received gentamicin/penicillin G (±metronidazole); OS patients received cefuroxime. Two days after surgery a second swab was taken. From SG patients, 6% of first swabs and 9% of second swabs were positive for ESBL-/AmpC-producers. A similar carriage rate was observed in OS patients (6% and 8%, respectively). No CPE were detected. Escherichia coli was the predominant species and blaCTX-M-15 (29% and 22%) and blaCTX-M-14 (11% and 17%) were the most prevalent ESBL genotypes among SG and OS patients. Two different prophylactic antibiotic regimens had no impact on carriage rates. Previous hospitalization and antimicrobial treatment were associated with carriage for SG patients.
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| http://dx.doi.org/10.1016/j.diagmicrobio.2016.07.028 | DOI Listing |
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