Background: Calciphylaxis is a rare disorder that is very unusual outside the setting of end-stage kidney disease.
Case Summary: A 64-year-old woman with normal renal function presented with painful leg ulcers. She had previously received 300 000 IU of vitamin D followed by daily calcium and vitamin D supplementation. A skin biopsy was consistent with calciphylaxis, and she was treated with sodium thiosulphate infusions and wound debridement.
Conclusion: Calcium and vitamin D supplements are widely prescribed. We report a case of calciphylaxis triggered by calcium and vitamin D supplementation in a patient with none of the typical risk factors. Our patient had an excellent response to treatment with sodium thiosulphate.
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