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Alzheimer's disease (AD) is a form of dementia in which memory and cognitive decline is thought to arise from underlying neurodegeneration. These cognitive impairments, however, are transient when they first appear and can fluctuate across disease progression. Here, we investigate the neural mechanisms underlying fluctuations of performance in amnestic mice.
View Article and Find Full Text PDFClinical criteria for limbic-predominant age-related TDP-43 encephalopathy.
Alzheimers Dement
January 2025
Rush University Medical Center, Chicago, Illinois, USA.
Limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is highly prevalent in late life and a common co-pathology with Alzheimer's disease neuropathologic change (ADNC). LATE-NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course.
View Article and Find Full Text PDFPerivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study.
Alzheimers Res Ther
October 2024
German Centre for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, Magdeburg, 39120, Germany.
Background: Perivascular space (PVS) enlargement in ageing and Alzheimer's disease (AD) and the drivers of such a structural change in humans require longitudinal investigation. Elucidating the effects of demographic factors, hypertension, cerebrovascular dysfunction, and AD pathology on PVS dynamics could inform the role of PVS in brain health function as well as the complex pathophysiology of AD.
Methods: We studied PVS in centrum semiovale (CSO) and basal ganglia (BG) computationally over three to four annual visits in 503 participants (255 females; mean = 70.
Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer's disease.
Alzheimers Res Ther
September 2024
Department of Diagnostic Radiology, Clinical Sciences, Lund University, Klinikgatan 13B, Lund, SE-22242, Sweden.
Article Synopsis
- The medial temporal lobe (MTL), thought to be relatively unaffected in early-onset Alzheimer's disease (EOAD), was examined in detail to understand atrophy patterns among different age groups of Alzheimer's patients.
- The study included participants with memory issues and abnormal brain scans, comparing 41 EOAD individuals under 65 years old with 154 late-onset Alzheimer's (aLOAD) patients aged 70 or older, alongside cognitively healthy controls.
- Findings revealed that both EOAD and aLOAD groups had smaller MTL regions compared to controls, with specific differences in brain structure and pathology but no significant differences in tau pathology levels between the two Alzheimer's groups.
Medial temporal lobe atrophy patterns in early- versus late-onset amnestic Alzheimer's disease.
bioRxiv
May 2024
Department of Diagnostic Radiology, Clinical Sciences, Lund University, 22242 Lund, Sweden.
Background: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.
Methods: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included.
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