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| http://dx.doi.org/10.1007/s11999-016-5042-6 | DOI Listing |
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Homonuclear decoupled INADEQUATE NMR methods with improved sensitivity and resolution in solid-state NMR.
J Magn Reson
January 2025
Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181, UCCS - Unité de Catalyse et Chimie du Solide, F-59000 Lille, France. Electronic address:
The two-dimensional (2D) refocused INADEQUATE NMR experiment, which correlates double-quantum (DQ) and single-quantum (SQ) coherences, is widely used to probe the chemical connectivities in solids. Nevertheless, the multiplets along the F dimension reduce the resolution and sensitivity of this experiment. The Composite-Refocusing (CR) technique with two excitation pulses has been proposed to suppress these multiplets in 2D INADEQUATE spectra of liquids.
View Article and Find Full Text PDFPathogenic variants in KMT2C result in a neurodevelopmental disorder distinct from Kleefstra and Kabuki syndromes.
Am J Hum Genet
August 2024
Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Health Innovation Manchester, Manchester, UK; Manchester Centre for Genomic Medicine, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Article Synopsis
- KMT2C and KMT2D are important enzymes that modify genes, with KMT2C haploinsufficiency recently linked to Kleefstra syndrome 2, a neurodevelopmental disorder (NDD) with unknown clinical details.
- A study involving 98 individuals found that most pathogenic variants in KMT2C span nearly all its exons, making variant interpretation difficult; the study also established a KMT2C DNA methylation signature for better classification of the disorder.
- Key features of KMT2C-related NDD include developmental delays, intellectual disabilities, and distinct facial characteristics, setting it apart from similar conditions like Kleefstra and Kabuki syndromes, indicating the need for its renaming and
Analysis during chest compressions in out-of-hospital cardiac arrest patients, a cross/sectional study: The DEFI 2022 study.
Resuscitation
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Paris Fire Brigade, 1 place Jules Renard, 75017 Paris, France.
Aims: During out-of-hospital cardiac arrest (OHCA), an automatic external defibrillator (AED) analyzes the cardiac rhythm every two minutes; however, 80% of refibrillations occur within the first minute post-shock. We have implemented an algorithm for Analyzing cardiac rhythm While performing chest Compression (AWC). When AWC detects a shockable rhythm, it shortens the time between analyses to one minute.
View Article and Find Full Text PDFFacial icons as indexes of emotions and intentions.
Front Psychol
May 2024
Department of Psychology, Faculty of Letters, Keio University, Tokyo, Japan.
Various objects and artifacts incorporate representations of faces, encompassing artworks like portraits, as well as ethnographic or industrial artifacts such as masks or humanoid robots. These representations exhibit diverse degrees of human-likeness, serving different functions and objectives. Despite these variations, they share common features, particularly facial attributes that serve as building blocks for facial expressions-an effective means of communicating emotions.
View Article and Find Full Text PDFTechnical challenges in REM sleep microstructure classification: A study of patients with REM sleep behaviour disorder.
J Sleep Res
December 2024
Psychology Department, Université de Montréal, Montréal, Québec, Canada.
While commonly treated as a uniform state in practice, rapid eye movement sleep contains two distinct microstructures-phasic (presence of rapid eye movement) and tonic (no rapid eye movement). This study aims to identify technical challenges during rapid eye movement sleep microstructure visual classification in patients with rapid eye movement sleep behaviour disorder, and to propose solutions to enhance reliability between scorers. Fifty-seven sleep recordings were randomly allocated into three subsequent batches (n = 10, 13 and 34) for scoring.
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