AI Article Synopsis
- Dieting can cause weight cycling, where individuals repeatedly lose and regain weight, but there's limited knowledge on blood markers that indicate overnutrition during this process.
- Research found that serum leukocyte cell-derived chemotaxin 2 (LECT2) quickly changed in response to diet shifts in obese mice, decreasing when switching from a high-fat diet to a regular diet and increasing with the opposite switch.
- LECT2 levels in the blood correlated with liver triglyceride content, suggesting it could be a useful marker for managing obesity.
Article Abstract
Dieting often leads to body weight cycling involving repeated weight loss and regain. However, little information is available regarding rapid-response serum markers of overnutrition that predict body weight alterations during weight cycling. Here, we report the rapid response of serum leukocyte cell-derived chemotaxin 2 (LECT2), a hepatokine that induces insulin resistance in skeletal muscle, during diet-induced weight cycling in mice. A switch from a high-fat diet (HFD) to a regular diet (RD) in obese mice gradually decreased body weight but rapidly decreased serum LECT2 levels within 10 days. In contrast, a switch from a RD to a HFD rapidly elevated serum LECT2 levels. Serum LECT2 levels showed a positive correlation with liver triglyceride contents but not with adipose tissue weight. This study demonstrates the rapid response of LECT2 preceding body weight alterations during weight cycling in mice and suggests that measurement of serum LECT2 may be clinically useful in the management of obesity.
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| http://dx.doi.org/10.1016/j.bbrc.2016.08.117 | DOI Listing |
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