AI Article Synopsis
- Managing acute leukemia in pregnant women is complex, with a study of 23 patients from the Mayo Clinic revealing significant challenges and outcomes over a 54-year period.
- About 50% of the patients experienced therapeutic terminations or spontaneous abortions, and those who delayed chemotherapy beyond one week had a higher risk of death during treatment.
- Despite the difficulties, 78% achieved complete remission, and by a median follow-up of 55 months, 30% of the patients studied remained alive, with no reported congenital malformations in newborns.
Article Abstract
Management of acute leukemia during pregnancy presents a considerable challenge. Herein, we review our experience of 23 patients diagnosed with acute leukemia; during pregnancy at the Mayo Clinic between 1962 and 2016. Ten (43.4%), seven (30.4%), and six (26.2%) patients were diagnosed in first, second, and third trimester, respectively. In approximately, 50% (n = 11) therapeutic terminations or spontaneous abortions occurred. Fifty percent (2/4) of patients diagnosed during either first or second trimester who delayed chemotherapy by greater than one week died during induction therapy. Eleven patients received chemotherapy while pregnant which led to four fetal losses and seven deliveries (five full-term and two preterm deliveries). No congenital malformations were reported. Eighteen patients (78%) achieved complete remission. At a median follow up of 55 months, seven patients (30%) remain alive. In summary, we provide a comprehensive description of maternal and fetal outcomes and insight into management of acute leukemia during pregnancy.
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| http://dx.doi.org/10.1080/10428194.2016.1222379 | DOI Listing |
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