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Cholelithiasis in Infants: Risk Factors, Management, and the Role of Ursodeoxycholic Acid.
Children (Basel)
December 2024
Department of Pediatrics, Division of Pediatric Gastroenterology, University of Health Sciences Dr. Behçet Uz Children's Hospital, Izmir 35210, Turkey.
Background: Cholelithiasis is a rare disease in infants, and there is limited data on its risk factors and management.
Objectives: To evaluate the risk factors, management, and response to medical treatment of cholelithiasis in infants.
Methods: Infants diagnosed with cholelithiasis by ultrasound between 2018 and 2023 were retrospectively analyzed.
Cornelia de Lange Syndrome Accompanied by Cholelithiasis and Nephrolithiasis: A Case Report.
Children (Basel)
November 2024
Departments of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan 49267, Republic of Korea.
Cornelia de Lange syndrome (CdLS) is a rare genetic disorder characterized by a distinctive facial appearance, growth/cognitive retardation, developmental delay, skeletal malformation, hypertrichosis, and other abnormalities. Patients with mild CdLS have less severe phenotypes, while retaining representative facial features. Mutations in the genes , , , , and have been associated with CdLS, with mutations in accounting for approximately 60% of cases.
View Article and Find Full Text PDFAssociation between metabolic dysfunction associated steatotic liver disease and gallstones in the US population using propensity score matching.
Sci Rep
January 2025
Department of General Surgery, The Affiliated Wuxi Fifth Hospital of Jiangnan University, No. 1215 Guangrui Road, Wuxi, 214005, Jiangsu, China.
The novel diagnostic term Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) requires at least one cardiovascular risk factor for diagnosis. While the relationship between gallstones and Non-Alcoholic Fatty Liver Disease (NAFLD) has been debated, the association between MASLD and gallstones remains unclear. This cross-sectional study aimed to explore this relationship using National Health and Nutrition Examination Survey (NHANES) data from 2017 to 2020.
View Article and Find Full Text PDFAssociation Between High-Density Lipoprotein Cholesterol and Length of Hospital Stay in Acute Pancreatitis: A Retrospective Cohort Study.
Int J Gen Med
December 2024
Department of Gastroenterology, Ningbo No. 2 Hospital, Ningbo, Zhejiang Province, 315010, People's Republic of China.
Background: Acute pancreatitis (AP) is a complex inflammatory disorder with varying degrees of severity, impacting patient recovery and healthcare resource utilization. The length of hospital stay (LOS) is a pivotal indicator of recovery, and identifying factors influencing LOS can offer insights into AP management. High-density lipoprotein cholesterol (HDL-C), known for its cardioprotective properties, has been posited to influence AP outcomes; however, its relationship with LOS remains unclear.
View Article and Find Full Text PDFExploring the causal impact of body mass index on metabolic biomarkers and cholelithiasis risk: a Mendelian randomization analysis.
Sci Rep
January 2025
The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Article Synopsis
- Obesity is a significant risk factor for diseases, but it's still unclear how it contributes to disease development, prompting a study using Mendelian randomization to analyze the relationship between BMI, metabolic traits, and cholelithiasis.
- BMI was found to positively affect the risk of developing cholelithiasis across multiple datasets, with 176 metabolites linked to BMI identified, including crucial fats and cholesterol types.
- The study highlights key metabolites that mediate the BMI-cholelithiasis connection, emphasizing the need for effective BMI management to reduce metabolic dysfunction and gallstone risk, while calling for further research into the underlying metabolic pathways.
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