AI Article Synopsis
- The study investigated the potential of matrix metalloproteinases (MMP) and tissue inhibitors (TIMP) as biomarkers for early detection and severity assessment of severe acute pancreatitis (SAP).
- Patients with acute pancreatitis showed significantly higher levels of MMP-8, -9, and TIMP-1 compared to controls, with MMP-8 effectively distinguishing severe cases from mild ones.
- While MMP-8 demonstrated strong predictive capability for SAP, MMP-7 and TIMP-1 showed weak correlation with creatinine levels and didn't differentiate between moderate and severe disease severity.
Article Abstract
Objectives: Several biomarkers for early detection of severe acute pancreatitis (SAP) have been presented. Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are released early in inflammation. We aimed to assess levels of MMP-7, -8, -9 and TIMP-1 in acute pancreatitis (AP) and explore their ability to detect disease severity. Our second aim was to find an association between MMPs, TIMP and creatinine.
Methods: We collected plasma samples for MMP-7, -8, -9 and TIMP-1 analyses from 176 patients presenting within 96 h from onset of acute pancreatitis (AP) symptoms. We used samples from 32 control subjects as comparison. The revised Atlanta Classification was utilised to assess severity of disease. Receiver operating characteristic curve analysis and Spearman´s Rho-test were utilised for statistical calculations.
Results: Compared with controls, patients showed higher levels of all studied markers. MMP-8 was higher in moderately severe AP than in mild AP (p = 0.005) and MMP-8, -9 and TIMP-1 were higher in severe than in mild AP (p<0.001, p = 0.005 and p = 0.019). MMP-8 detected SAP with an AUC of 0.939 [95% CI 0.894-0.984], LR+ 9.03 [5.30-15.39]. MMP-8, -9 and TIMP-1 failed to discern moderately severe AP from SAP. MMP-7 was not different between patient groups. MMP-7 and TIMP-1 correlated weakly with creatinine (Rho = 0.221 and 0.243). MMP-8 might be a useful biomarker in early detection of SAP.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999158 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161480 | PLOS |
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