AI Article Synopsis
- Research is focusing on analyzing methionine pathway metabolites, which are important for health management, but requires multiple analytical methods for different metabolites and co-factors.
- A new method has been developed to detect and measure 13 metabolites in red blood cells, proving to be accurate and reliable when tested on healthy individuals.
- This efficient, high-throughput method allows for comprehensive analysis of key metabolites in just one test, promising to enhance nutritional research in both health and disease contexts.
Article Abstract
Aim: There is increasing interest in the profiling and quantitation of methionine pathway metabolites for health management research. Currently, several analytical approaches are required to cover metabolites and co-factors.
Results: We report the development and the validation of a method for the simultaneous detection and quantitation of 13 metabolites in red blood cells. The method, validated in a cohort of healthy human volunteers, shows a high level of accuracy and reproducibility.
Conclusion: This high-throughput protocol provides a robust coverage of central metabolites and co-factors in one single analysis and in a high-throughput fashion. In large-scale clinical settings, the use of such an approach will significantly advance the field of nutritional research in health and disease.
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| http://dx.doi.org/10.4155/bio-2016-0112 | DOI Listing |
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