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Deep learning model for personalized prediction of positive MRSA culture using time-series electronic health records.
Nat Commun
March 2024
McWilliams School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
Methicillin-resistant Staphylococcus aureus (MRSA) poses significant morbidity and mortality in hospitals. Rapid, accurate risk stratification of MRSA is crucial for optimizing antibiotic therapy. Our study introduced a deep learning model, PyTorch_EHR, which leverages electronic health record (EHR) time-series data, including wide-variety patient specific data, to predict MRSA culture positivity within two weeks.
View Article and Find Full Text PDFAntimicrobial and Anti-Biofilm Activities of Coffea arabica L. Against the Clinical Strains Isolated From Diabetic Foot Ulcers.
Cureus
January 2024
Medical Microbiology, University of Tabuk, Tabuk, SAU.
Diabetes-related complications such as diabetic foot infections foster resilient biofilms, complicating treatment. Innovative therapeutic solutions are urgently needed to address this challenge. In this research, coffee bean powder (green coffee been powder [GCBP], roasted coffee bean powder [RCBP], and spent coffee powder ground [SCPG]) was extracted and assessed for its ability to impede biofilm formation and associated functions in extended-spectrum beta-lactamase (ESBL) and methicillin-resistant (MRSA)-positive biofilm-forming strains of , , and obtained from foot ulcers.
View Article and Find Full Text PDFDescriptive evaluation of patients receiving one-time intravenous vancomycin doses at a large academic medical center emergency department.
Am J Emerg Med
March 2024
Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC, USA.
Background: Intravenous (IV) vancomycin is commonly used to treat a variety of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). The practice of administering a single dose of IV vancomycin prior to emergency department (ED) discharge may be clinically ineffective and foster antimicrobial resistance. Furthermore, this practice introduces an unnecessary infection risk along with preventable adverse effects while potentially increasing ED length of stay (LOS).
View Article and Find Full Text PDFHealth care worker carriage of drug-resistant bacteria and infection control practices at a tertiary care hospital in Uganda: a cross-sectional survey.
Pan Afr Med J
August 2023
Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Introduction: bacterial carriage by health care workers (HCWs) is a major risk factor for transmission of healthcare-associated infections (HAIs). Often, these pathogens are multiple drug resistant (MDR) and are transmitted from hospital environments. We aimed to study the carriage of pathogenic bacteria among HCWs at a tertiary care hospital in Uganda.
View Article and Find Full Text PDFAntimicrobial Resistance and Molecular Characterization of Methicillin-Resistant from Two Pig Farms: Longitudinal Study of LA-MRSA.
Antibiotics (Basel)
November 2022
Institute of Microbiology and Parasitology, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, SI-1000 Ljubljana, Slovenia.
Pigs were identified as the most important reservoir of livestock-associated methicillin-resistant (LA-MRSA), mostly belonging to the emergent zoonotic clonal complex (CC) 398. Here, we investigated the presence of MRSA in sows and piglets over a period of several months in two pig farms (intensive farm A and family-run farm B). Isolates underwent antimicrobial susceptibility testing, PCR characterization and typing.
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