The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383693 | PMC |
| http://dx.doi.org/10.1007/s00294-016-0642-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The GSAG:Ce scintillator represents a promising and cost-effective alternative to the expensive GGAG:Ce. Recent studies have attributed its low light yield to the thermal quenching effect. In this study, we employed the strategy of adding an yttrium (Y) admixture to the GSAG matrix to increase the thermal activation energy of thermal quenching.
View Article and Find Full Text PDFand hybrid approach to unveil triterpenoids from leaves as potential compounds for inhibiting Nrf2.
RSC Adv
January 2025
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University No. 100, Shih-Chuan 1st Road, Sanmin District Kaohsiung City 80708 Taiwan.
Cancer is a leading global health concern, with over 20 million new cases and 9.7 million deaths reported in 2022. Chemotherapy remains a widely used treatment, but drug resistance, which affects up to 90% of treatment outcomes, significantly hampers its effectiveness.
View Article and Find Full Text PDFOrigin of C NMR chemical shifts elucidated based on molecular orbital theory: paramagnetic contributions from orbital-to-orbital transitions for the pre-α, α, β, α-X, β-X and -X effects, along with effects from characteristic bonds and groups.
RSC Adv
January 2025
Faculty of Systems Engineering, Wakayama University 930 Sakaedani Wakayama 640-8510 Japan
C NMR chemical shifts ((C)) were analysed MO theory, together with the origin, using (C), (C) and (C), where C was selected as the standard for the analysis since (C: C) = 0 ppm. An excellent relationship was observed between (C) and the charges on C for (C, C, C, C and C) and (C, CH , CH and CH). However, such a relationship was not observed for the carbon species other than those above.
View Article and Find Full Text PDFA Structural Model of Truncated Gaussia princeps Luciferase Elucidating the Crucial Catalytic Function of No.76 Arginine towards Coelenterazine Oxidation.
PLoS Comput Biol
January 2025
College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, People's Republic of China.
Gaussia Luciferase (GLuc) is a renowned reporter protein that can catalyze the oxidation of coelenterazine (CTZ) and emit a bright light signal. GLuc comprises two consecutive repeats that form the enzyme body and a central putative catalytic cavity. However, deleting the C-terminal repeat only limited reduces the activity (over 30% residual luminescence intensity detectable), despite being a key part of the cavity.
View Article and Find Full Text PDFUnraveling the structure-property relationships in fluorescent phenylhydrazones: the role of substituents and molecular interactions.
RSC Adv
January 2025
Institute of Polymer and Dye Technology, Lodz University of Technology Stefanowskiego 16 Lodz 90537 Poland.
This study investigates the structure-property relationships of a series of phenylhydrazones bearing various electron-donating and electron-withdrawing substituents, such as methoxy, dimethylamino, morpholinyl, hydroxyl, chloro, bromo, and nitro groups. The compounds were synthesized, and their structures were characterized using single-crystal X-ray diffraction, powder X-ray diffraction, FTIR spectroscopy, NMR spectroscopy, and DSC. Three-dimensional excitation-emission matrix (3D-EEM) fluorescence spectroscopy and UV-Vis spectroscopy were employed to elucidate the complex interplay between the molecular skeleton, substituents, and the resulting photophysical properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!