Aspecific Uptake of 68GA-PSMA in Paget Disease of the Bone.

Clin Nucl Med

From the *Department of Nuclear Medicine, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende, Brugge; and †Department of Nuclear Medicine, Universitair Ziekenhuis Brussel, Brussel, Belgium.

Published: November 2016

Ga-PSMA plays an increasing role in prostate cancer management, but several instances of false positivity have now been recognized. We present a patient with metastatic prostatic carcinoma who also showed overexpression of PSMA in Paget disease of the humerus on Ga-PSMA PET. This probably relates to bone remodeling and increased vascularity. It is important to be aware of this aspecific uptake because its recognition may avoid overstaging and may alter the therapeutic choice.

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Source
http://dx.doi.org/10.1097/RLU.0000000000001335DOI Listing

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