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Histological assessment of extensive or unresectable central giant cell granulomas treated with denosumab - A case series.
Oral Surg Oral Med Oral Pathol Oral Radiol
November 2024
Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, Kuala Lumpur, Malaysia; Faculty of Dentistry, Oral, and Craniofacial Sciences, King's College London, Great Maze Pond, London, United Kingdom.
Objective: The management of large central giant cell granuloma (CGCG) can pose a significant surgical challenge. In such circumstances, the use of denosumab has been proposed with the literature reporting varying degrees of success. Histopathological assessment of CGCG post-denosumab treatment remains unknown.
View Article and Find Full Text PDFBeyond the rare: a case of pseudomyogenic hemangioendothelioma treated sequentially with everolimus, denosumab, and pazopanib.
Einstein (Sao Paulo)
December 2024
Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Pseudomyogenic hemangioendothelioma is an ultra-rare vascular sarcoma that most commonly affects young adults, with a male predominance. It is diagnosed using a combination of imaging studies, histopathological examinations, and immunohistochemical staining. Surgical excision is the mainstay of treatment for pseudomyogenic hemangioendothelioma, with the goal of achieving a wide local excision and reducing the risk of recurrence.
View Article and Find Full Text PDFIn silicon desinging of RANKL-targeting vaccine for protection of osteoporosis based on the epitope of Denosumab.
Int Immunopharmacol
January 2025
Orthopaedic Centre, The University of Hong Kong Shenzhen Hospital, Shenzhen, Guangdong 518000, China. Electronic address:
Background: Life quality of osteoporosis patients is affected significantly due to the severely complications of fracture and pain. RANKL, indicated as the key mediator of osteoporosis, plays a pathogenic role of osteoclasts induction. To target this program, two medications, bisphosphonate and Denosumab, were developed and achieved remarkable advantages in clinics.
View Article and Find Full Text PDF[Long-Term Response to CDK4/6 Inhibitor for Multiple Metastases of Breast Cancer].
Gan To Kagaku Ryoho
October 2024
Dept. of Breast and Endocrine Surgery, Nippon Dental University Hospital.
The patient was a 60-year-old woman. She was diagnosed with hypertension, symptomatic epilepsy, renal failure, and cerebral infarction. During follow-up, she was found to have a mass in her left breast and was referred to our department.
View Article and Find Full Text PDFParathyroid Carcinoma Complicated by Parathyromatosis and Refractory Hypercalcemia.
Cureus
October 2024
Department of Endocrinology Diabetes Medicine, Samatvam Diabetes Endocrinology and Medical Center Samatvam: Science and Research for Human Welfare Trust, Bangalore, IND.
Parathyroid carcinoma (PC) is a rare malignancy. In January 2022, a 41-year-old woman presented with weight loss, proximal muscle weakness, and bone pain. She was diagnosed with severe hypercalcemia with serum calcium of 15.
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