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Evaluating the Diagnostic Value of Lymphocyte Subsets in Bronchoalveolar Lavage Fluid and Peripheral Blood Across Various Diffuse Interstitial Lung Disease Subtypes.
Biomolecules
January 2025
Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo 113-8421, Japan.
Diffuse interstitial lung diseases (ILD) include conditions with identifiable causes such as chronic eosinophilic pneumonia (CEP), sarcoidosis (SAR), chronic hypersensitivity pneumonitis (CHP), and connective tissue disease-associated interstitial pneumonia (CTD), as well as idiopathic interstitial pneumonia (IIP) of unknown origin. In non-IIP diffuse lung diseases, bronchoalveolar lavage (BAL) fluid appearance is diagnostic. This study examines lymphocyte subsets in BAL fluid and peripheral blood of 56 patients with diffuse ILD, excluding idiopathic pulmonary fibrosis (IPF), who underwent BAL for diagnostic purposes.
View Article and Find Full Text PDFFungal Osteomyelitis of a Diabetic Foot Infection Caused by Trichosporon asahii: A Case Report.
Adv Skin Wound Care
January 2025
At Baylor College of Medicine, Houston, Texas, United States, Livia Frost, BS, is Medical Student, School of Medicine; Ya Xu, MD, PhD, is Assistant Professor, Department of Pathology & Immunology; and Yuriko Fukuta, MD, PhD, CWSP, is Assistant Professor, Department of Medicine, Section of Infectious Diseases.
Diabetic foot bacterial osteomyelitis is a serious infection that can lead to major amputations. However, fungal osteomyelitis in a diabetic foot ulcer is uncommon and has been underrecognized. It typically occurs in patients with underlying immunocompromised status and is associated with poor outcomes.
View Article and Find Full Text PDFPredictive factors of progression in mild fibrosing interstitial lung disease patients with gender-age-physiology score of 3 or less.
Respir Investig
January 2025
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Article Synopsis
- The study aimed to identify prognostic factors for annual progression in mild fibrosing interstitial lung disease (FILD) using retrospective data and logistic regression analysis.
- Significant factors associated with progression included the diagnosis of specific lung diseases, patient-reported outcomes, changes in lung function tests, and the CT scan's appearance.
- The findings suggest that factors such as exercise-induced hypoxia, radiological patterns, and certain disease diagnoses are key predictors of how FILD may worsen over time.
Hypersensitivity pneumonitis radiologic features in interstitial lung diseases.
Respir Med
January 2025
Center of Excellence for Interstitial Lung Diseases, Tel Aviv Medical Center, Tel Aviv University, Israel; Institute of Pulmonary Medicine, Tel Aviv Medical Center, Tel Aviv University, Israel. Electronic address:
Background: The radiologic criteria of hypersensitivity pneumonitis (HP) guidelines focus on four HP compatible features (HPCF) in high-resolution computed tomography (HRCT): ground glass opacities, mosaic attenuation, air-trapping, and centrilobular nodules. However, evidence to support these criteria are limited.
Methods: Consecutive interstitial lung disease (ILD) patients who underwent HRCT between 2016 and 2021 in three medical centers were included.
Diagnostic potential of genomic blood biomarkers of pulmonary fibrosis in a prospective cohort.
PLoS One
December 2024
Department of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Article Synopsis
- * This study used a specialized 166-gene NanoString test on whole blood to find distinct gene expressions for different ILD subtypes, discovering KLRF1 as a key marker differentiating idiopathic pulmonary fibrosis (IPF) from systemic sclerosis-associated ILD (SSc-ILD).
- * Validation studies showed that KLRF1 levels were significantly higher in SSc-ILD compared to IPF and hypersensitivity pneumonitis, suggesting that analyzing blood transcripts can help identify relevant biomarkers
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