A new study reveals that a protein called talin forms a vital link between microtubules and focal adhesions at the surface of cells.
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| http://dx.doi.org/10.7554/eLife.19733 | DOI Listing |
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Tackling the primary healthcare workforce crisis: time to talk about health systems and governance-a comparative assessment of nine countries in the WHO European region.
Hum Resour Health
December 2024
Department of Public Health, University of Aarhus, Aarhus, Denmark.
Background: Primary healthcare has emerged as a powerful global concept, but little attention has been directed towards the pivotal role of the healthcare workforce and the diverse institutional setting in which they work. This study aims to bridge the gap between the primary healthcare policy and the ongoing healthcare workforce crisis debate by introducing a health system and governance approach to identify capacities that may help respond effectively to the HCWF crisis in health system contexts.
Methods: A qualitative comparative methodology was employed, and a rapid assessment of the primary healthcare workforce was conducted across nine countries: Denmark, Germany, Kazakhstan, Netherlands, Portugal, Romania, Serbia, Switzerland, and the United Kingdom/ England.
Novel research model for in vitro immunotherapy: co-culturing tumor organoids with peripheral blood mononuclear cells.
Cancer Cell Int
December 2024
Division of Cancer Biology, Laboratory Animal Center, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Tumor organoids have emerged as powerful tools for in vitro cancer research due to their ability to retain the structural and genetic characteristics of tumors. Nevertheless, the absence of a complete tumor microenvironment (TME) limits the broader application of organoid models in immunological studies. Given the critical role of immune cells in tumor initiation and progression, the co-culture model of organoids and peripheral blood mononuclear cells (PBMCs) may provide an effective platform for simulating the interactions between immune and tumor cells in vitro.
View Article and Find Full Text PDFAssociation between biomass cooking fuels and prevalence of tuberculosis among households: a cross-sectional study from 2019 - 2021 in India.
BMC Public Health
December 2024
Department of Chemistry, College of Natural and Computational Sciences, Wollega University, P.O. Box 395, Nekemte, Ethiopia.
Background: Indoor air pollution (IAP) is the major contributor (26%) to TB, in addition to other socioeconomic and environmental factors. It occurs in most developing countries like India, where people rely on the combustion of biomass-based solid fuels (low combustion efficiency and high pollution emissions) due to the prevailing socio-economic conditions. However, this cause-and-effect relationship between TB and IAP has not been studied much.
View Article and Find Full Text PDFLinear and nonlinear record high optical birefringence in anisotropic van der Waals crystals.
Light Sci Appl
January 2025
Chair in Hybrid Nanosystems, Faculty of Physics, Ludwig-Maximilians-Universität München, 80539, Munich, Germany.
Multilayered van der Waals (vdW) materials are semiconductors composed of atomically thin crystal layers, held together by weak vdW forces. They offer unique crystal structures and electronic properties, distinct from conventional semiconductors, making them a promising platform for linear and nonlinear optics. In this context, the large refractive indexes given by highly polarizable transition metals, combined with excitonic resonances and unconventional crystalline structures, provides a toolbox for exploring non-linear physics and strong light-matter interactions with unprecedented opportunities for nanoscale optics.
View Article and Find Full Text PDFOptimizing length of hospital stay among inpatients with spinal cord injury: An observational study.
J Healthc Qual Res
December 2024
Department of Research and Innovation, Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.
Introduction And Objectives: Despite the importance of length of stay (LOS) following spinal cord injury, it remains underexplored in the literature. This study aims to bridge this gap by investigating the association between rehabilitation LOS and functional gains among patients with traumatic (TSCI) or non-traumatic (NTSCI) spinal cord injuries.
Methods: We conducted a retrospective observational cohort study assessing functional gains using the motor Functional Independence Measure (mFIM) and the Spinal Cord Independence Measure (SCIM III) from rehabilitation admission to discharge.
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