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- Liquid biopsy (LB) with FoundationOne Liquid CDx (F1L CDx) offers a non-invasive way to detect genetic changes in advanced non-small cell lung cancer (NSCLC) patients when tissue biopsies aren't possible, and this study assesses its cost-effectiveness in Spain.
- In a model evaluating 1,000 patients, F1L CDx identified 386 alterations, enabling targeted treatments and yielding significant health benefits compared to traditional non-molecular diagnosis, evidenced by an additional 383.95 life years (LYs) and 305.94 quality-adjusted life years (QALYs) despite a higher overall cost of €2,898,308.
- The analysis concludes that F1L CDx
Multiplex molecular assays for the laboratory-based and point-of-care diagnosis of infections caused by seasonal influenza, COVID-19, and RSV.
Expert Rev Mol Diagn
November 2024
Hygiene Unit, San Martino Policlinico Hospital - IRCCS for Oncology and Neurosciences, Genoa, Italy.
Introduction: SARS-CoV-2, seasonal influenza, and respiratory syncytial virus (RSV) are major causes of acute respiratory infections in all age groups and responsible for an enormous socio-economic burden. The recently coined term 'tripledemic' describes co-circulation of these three viruses, a novel epidemiological paradigm that poses profound public health implications.
Areas Covered: Real-time reverse transcription polymerase chain reaction (RT-PCR) is now considered the reference method for the diagnosis of SARS-CoV-2, influenza, and RSV infections.
Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses.
J Infect Public Health
December 2023
Department of Convergence Engineering, Graduate School of Venture, Hoseo University, Seoul, 06724, South Korea. Electronic address:
Background: Multiplex real-time PCR is a quick and cost effective method for detection of various gene simultaneously. HFSV (Hemorrhagic Fever Syndrome Virus) is a newly emerging infectious disease because of globalization and climate change. We tried to develop a molecular diagnostic technique for various causative viruses and evaluate its usefulness for improving public health.
View Article and Find Full Text PDFCombining phytoremediation with bioenergy production: developing a multi-criteria decision matrix for plant species selection.
Environ Sci Pollut Res Int
March 2023
Department of Natural Sciences, Faculty of Science and Technology, Middlesex University, The Burroughs, London, NW4 4BT, UK.
The use of plants to extract metal contaminants from soils has been proposed as a cost-effective means of remediation, and utilizing energy crops for this phytoextraction process is a useful way of attaining added value from the process. To simultaneously attain both these objectives successfully, selection of an appropriate plant species is crucial to satisfy a number of imporTant criteria including translocation index, metal and drought tolerance, fast growth rate, high lignocellulosic content, good biomass production, adequate calorific value, second generation attribute, and a good rooting system. In this study, we proposed a multi-criteria decision analysis (MCDA) to aid decision-making on plant species based on information generated from a systematic review survey.
View Article and Find Full Text PDFProspective study of diagnostic accuracy in the detection of high-grade prostate cancer in biopsy-naïve patients with clinical suspicion of prostate cancer who underwent the Select MDx test.
Prostate
September 2021
Department of Urology, Institute of Biomedicine of Seville (IBIS), Virgen del Rocio University Hospital (HVR), Seville, Spain.
Objectives: This study aimed to externally validate the diagnostic accuracy of the Select MDx test for Significant prostate cancer (Sig PCa) (ISUP > 1), in a contemporaneous, prospective, multicenter cohort with a prostate-specific antigen (PSA) between 3 and 10 ng/ml and a non-suspicious digital rectal examination.
Methods And Participants: For all enrolled patients, the Select Mdx test, the risk calculator ERSPC3 + DRE, and a prostatic magnetic resonance imaging (MRI) were carried out. Subsequently, a systematic 12-core trans-rectal biopsy and a targeted biopsy, in the case of a prostate imaging-reporting and data system (PIRADS) > 2 lesion (max three lesions), were performed.
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