Increases in eosinophil numbers are associated with infection and allergic diseases, including asthma, but there is also evidence that eosinophils contribute to homeostatic immune processes. In mice, the normal lung contains resident eosinophils (rEos), but their function has not been characterized. Here, we have reported that steady-state pulmonary rEos are IL-5-independent parenchymal Siglec-FintCD62L+CD101lo cells with a ring-shaped nucleus. During house dust mite-induced airway allergy, rEos features remained unchanged, and rEos were accompanied by recruited inflammatory eosinophils (iEos), which were defined as IL-5-dependent peribronchial Siglec-FhiCD62L-CD101hi cells with a segmented nucleus. Gene expression analyses revealed a more regulatory profile for rEos than for iEos, and correspondingly, mice lacking lung rEos showed an increase in Th2 cell responses to inhaled allergens. Such elevation of Th2 responses was linked to the ability of rEos, but not iEos, to inhibit the maturation, and therefore the pro-Th2 function, of allergen-loaded DCs. Finally, we determined that the parenchymal rEos found in nonasthmatic human lungs (Siglec-8+CD62L+IL-3Rlo cells) were phenotypically distinct from the iEos isolated from the sputa of eosinophilic asthmatic patients (Siglec-8+CD62LloIL-3Rhi cells), suggesting that our findings in mice are relevant to humans. In conclusion, our data define lung rEos as a distinct eosinophil subset with key homeostatic functions.
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http://dx.doi.org/10.1172/JCI85664 | DOI Listing |
Materials (Basel)
January 2025
Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia.
In situ measurements of the chemical identity and quantity of anode gases during electrochemical measurements and rare earth (RE) electrolysis from fluoride-based molten salts composed of different kinds of rare earth oxides (REOs) were performed using FTIR spectrometry. Linear sweep voltammetry (LSV) was carried out to characterize oxidation processes and determine the anodic effect from NdF + PrF + LiF + REO melt. RE complex formation and subsequent reactions on the GC anode surface were discussed to understand the formation pathways of CO/CO and perfluorocarbon gases (PFC), mainly CF and CF.
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December 2024
Hunan Provincial Key Laboratory of Geochemical Processes and Resource Environmental Effects, Changsha, Hunan 410014, China.
The largest negative carbon-isotope excursion in geological history has been reported by several studies of the upper Doushantuo Formation of South China, which has been correlated to the middle Ediacaran-Shuram excursion (SE). Due to a scarcity of radiometric age constraints on the excursion in South China, however, global correlations and comparisons of this event remain a debate. Here, we present Re-Os and carbon isotope data on organic-rich sediments obtained from a drill-core sample in the Chengkou area, the northeastern margin of the Yangtze Platform, and South China.
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January 2025
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Solid-phase rare earth monoxides have been recently synthesized thin film epitaxy. However, it has been difficult to synthesize heavy rare earth monoxides owing to their severe chemical instability. In this study, rocksalt-type heavy rare earth monoxides REOs (RE = Tb, Dy, Er) were synthesized for the first time, as single-phase epitaxial thin films.
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December 2024
Department of Systems Innovation, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Zhonghua Yu Fang Yi Xue Za Zhi
November 2024
Fujian Key Laboratory of Medical Bioinformatics, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou350122, China.
To construct a signature for identifying active tuberculosis (TB) based on the relative expression orderings (REOs) of gene expression within a single sample. Using peripheral whole blood samples from 75 active TB and 69 latently infected individuals from four datasets as the training set, and highly stable REO patterns were extracted from the gene expression profile of the two groups of samples. Then, the gene pairs that reversed the REO pattern between the two groups were selected, and each gene pair was ranked in descending order based on their reversal degree.
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