Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030165 | PMC |
| http://dx.doi.org/10.1038/nchembio.2157 | DOI Listing |
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