AI Article Synopsis
- Hereditary bisalbuminemia is a rare condition causing two albumin fractions in serum, typically identified incidentally and associated with a genetic mutation, which can be effectively detected using capillary zone electrophoresis (CZE).
- In a study of 40 bottlenose dolphins, 9 showed a double albumin peak in CZE, while agarose gel electrophoresis (AGE) did not always reveal the same results, indicating AGE's limitations in detecting this condition.
- The abnormality was found in two dolphin families, with all siblings in one family affected, highlighting the genetic inheritance pattern of the bisalbuminemia in marine mammals.
Article Abstract
Background: Hereditary bisalbuminemia is a relatively rare anomaly characterized by the occurrence of two albumin fractions on serum protein separation by electrophoresis. In human medicine, it is usually revealed by chance, is not been clearly associated with a specific disease and the causative genetic alteration is a point mutation of human serum albumin gene inherited in an autosomal codominant pattern. This type of alteration is well recognizable by capillary zone electrophoresis (CZE), whilst agarose gel electrophoresis (AGE) not always produces a clear separation of albumin fractions. The aims of this study is to report the presence of this abnormality in two separate groups of related bottlenose dolphins and to compare the results obtained with capillary zone and agarose gel electrophoresis.
Results: Serum samples from 40 bottlenose dolphins kept under human care were analyzed. In 9 samples a double albumin peak was evident in CZE electrophoresis while no double peak was noted in AGE profile. Since only an apparently wider albumin peaks were noted in some AGE electrophoretic profiles, the ratio between base and height (b/h) of the albumin peak was calculated and each point-value recorded in the whole set of data was used to calculate a receiver operating characteristic curve: when the b/h ratio of albumin peak was equal or higher than 0.25, the sensitivity and specificity of AGE to detect bisalbuminemic samples were 87 and 63 %, respectively. The bisalbuminemic dolphins belong to two distinct families: in the first family, all the siblings derived from the same normal sire were bisalbuminemic, whereas in the second family bisalbuminemia was present in a sire and in two out of three siblings.
Conclusions: We report for the first time the presence of hereditary bisalbuminemia in two groups of related bottlenose dolphins identified by means of CZE and we confirm that AGE could fail in the identification of this alteration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992212 | PMC |
| http://dx.doi.org/10.1186/s12917-016-0801-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characteristics of neutrophil chemotaxis in bottlenose dolphin (Tursiops truncatus).
Vet Immunol Immunopathol
January 2025
Laboratory of Preventive Veterinary Medicine and Animal Health, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa-ken 252-0880, Japan. Electronic address:
Cetaceans have adapted to aquatic life by evolving various anatomic and physiologic traits, but biological defense mechanisms specific to aquatic mammals that protect against pathogenic microorganisms in the aquatic environment have not been elucidated. In this study, we investigated the migration of polymorphonuclear leukocytes in bottlenose dolphins in response to various chemotactic factors and compared the migration response with that of terrestrial animals such as cows and humans to characterize biological defense mechanisms unique to cetaceans. Bottlenose dolphin neutrophils showed strong chemotactic activity toward zymosan-activated serum and recombinant human interleukin-8 but no chemotaxis toward N-formyl-methionyl-leucyl-phenylalanine or leukotriene B at any concentration examined.
View Article and Find Full Text PDFThe development of deep convolutional generative adversarial network to synthesize odontocetes' clicks.
J Acoust Soc Am
January 2025
Key Laboratory of Underwater Acoustic Communication and Marine Information Technology of the Ministry of Education, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361005, China.
Odontocetes are capable of dynamically changing their echolocation clicks to efficiently detect targets, and learning their clicking strategy can facilitate the design of man-made detecting signals. In this study, we developed deep convolutional generative adversarial networks guided by an acoustic feature vector (AF-DCGANs) to synthesize narrowband clicks of the finless porpoise (Neophocaena phocaenoides sunameri) and broadband clicks of the bottlenose dolphins (Tursiops truncatus). The average short-time objective intelligibility (STOI), spectral correlation coefficient (Spe-CORR), waveform correlation coefficient (Wave-CORR), and dynamic time warping distance (DTW-Distance) of the synthetic clicks were 0.
View Article and Find Full Text PDFIdentification of Two Common Bottlenose Dolphin () Ecotypes in the Guadeloupe Archipelago, Eastern Caribbean.
Animals (Basel)
January 2025
Institut de Systématique, Évolution, Biodiversité (ISYEB), Muséum National d'Histoire Naturelle, CNRS, Sorbonne Université, EPHE-PSL, Université des Antilles, 75005 Paris, France.
The common bottlenose dolphin () exhibits significant intraspecific diversity globally, with distinct ecotypes identified in various regions. In the Guadeloupe archipelago, the citizen science NGO OMMAG has been monitoring these dolphins for over a decade, documenting two distinct morphotypes. This study investigates whether these morphotypes represent coastal and oceanic ecotypes, which have not been previously identified in the region.
View Article and Find Full Text PDFLong-Term Demographic Trends of Near Threatened Coastal Dolphins Living in an Urban Estuary.
Ecol Evol
January 2025
Whale and Dolphin Conservation Adelaide South Australia Australia.
Understanding population demography of threatened species and how they vary in relation to natural and anthropogenic stressors is essential for effective conservation. We used a long-term photographic capture-recapture dataset (1993-2020) of Indo-Pacific bottlenose dolphins () in the highly urbanised Adelaide Dolphin Sanctuary (ADS), South Australia, to estimate key demographic parameters and their variability over time. These parameters were analysed in relation to environmental variables used as indicators of local and large-scale climatic events.
View Article and Find Full Text PDFLiver Lesions in Estuarine Dolphins in the Indian River Lagoon, Florida: Does Microcystin Play a Role?
Toxics
November 2024
Department of Ocean Engineering and Marine Sciences, Florida Institute of Technology, Melbourne, FL 32901, USA.
Microcystin (MC), a hepatotoxin produced by cyanobacteria, was introduced into the Indian River Lagoon (IRL), Florida, in 2005 through freshwater outflows. Since then, MC has been detected in humans, domestic animals, and wildlife in the lagoon. Potential public health effects associated with MC exposure along the IRL include an increased risk of non-alcoholic liver disease among area residents.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!