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Recent and future trends in osteopathic orthopedic surgery residency match rates following the transition to a single accreditation system.
J Osteopath Med
January 2025
Department of Orthopedic Surgery, Yale Medicine, Orthopedics and Rehabilitation, New Haven, CT, USA.
Context: Medical education in the United States has undergone significant changes, specifically within the osteopathic community. In 2020, a merger occurred between the American Osteopathic Association (AOA) and the Accreditation Council for Graduate Medical Education (ACGME), forming a single accreditation system (SAS) for graduate medical education and residency placement, with the purpose to create consistency within graduate medical education and to provide equal opportunities for applicants pursuing all specialties in medicine. However, osteopathic medical students, especially students applying to competitive residencies including orthopedic surgery, have faced challenges, raising concerns about future implications within this field.
View Article and Find Full Text PDFCobalt-based Photocatalysis: From Fundamental Principles to Applications in the Generation of C-X (X = C, O, N, H, Si) Bond.
Chemistry
January 2025
Jadavpur University, Chemistry, PG Science building, 700032, Kolkata, INDIA.
Over the past few decades, the merger of photocatalysis and transition metal-based catalysis or self-photoexcitation of transition metals has emerged as a useful tool in organic transformations. In this context, cobalt-based systems have attracted significant attention as sustainable alternatives to the widely explored platinum group heavy metals (iridium, rhodium, ruthenium) for photocatalytic chemical transformations. This review encompasses the basic types of cobalt-based homogeneous photocatalytic systems, their working principles, and the recent developments (2018-2024) in C-X (X = C, N, O, H, Si) bond formations.
View Article and Find Full Text PDFInference of multiple mergers while dating a pathogen phylogeny.
Syst Biol
January 2025
School of Life Sciences and Department of Statistics, University of Warwick, UK.
The vast majority of pathogen phylogenetic studies do not consider the possibility of multiple merger events being present, where a single node of the tree leads to more than two descendent branches. These events are however likely to occur when studying a relatively small population or if there is high variability in the reproductive chances. Here we consider the problem of detecting the presence of multiple mergers in the context of dating a phylogeny, that is determining the date of each of the nodes.
View Article and Find Full Text PDFFragmenstein: predicting protein-ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding-based methodology.
J Cheminform
January 2025
Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford, UK.
Current strategies centred on either merging or linking initial hits from fragment-based drug design (FBDD) crystallographic screens generally do not fully leaverage 3D structural information. We show that an algorithmic approach (Fragmenstein) that 'stitches' the ligand atoms from this structural information together can provide more accurate and reliable predictions for protein-ligand complex conformation than general methods such as pharmacophore-constrained docking. This approach works under the assumption of conserved binding: when a larger molecule is designed containing the initial fragment hit, the common substructure between the two will adopt the same binding mode.
View Article and Find Full Text PDFThe impact of osteopathic recognition on multiple medical specialty residencies in a university-based setting.
J Osteopath Med
January 2025
Department of Internal Medicine and Department of Pediatrics and Adolescent Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, USA.
Context: In 2020, the allopathic and osteopathic residency programs were merged into a single residency system, with the Accreditation Council for Graduate Medical Education (ACGME) as the sole accreditor for residencies and fellowships in the United States. As a result of this merger, osteopathic recognition (OR) emerged as a unique approach to promoting osteopathic training and practice. However, there is a lack of data on the effects of OR in residency, specifically university-based residency programs.
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