AI Article Synopsis
- Fucans are sulfated polysaccharides from the seaweed Spatoglossum schröederi, with fucan A being the most prominent and non-toxic to normal cells and rats.
- Silver nanoparticles containing fucan A were created using green chemistry, measuring 210nm, and maintaining stability for 14 months.
- These nanoparticles effectively reduced viability in renal adenocarcinoma cells (786-0) while showing no toxic effects on normal cell lines, indicating potential for targeted cancer therapy.
Article Abstract
Polysaccharides containing sulfated L-fucose are often called fucans. The seaweed Spatoglossum schröederi synthesizes three fucans, among which fucan A is the most abundant. This polymer is not cytotoxic against various normal cell lines and is non-toxic to rats when administered at high doses. In addition, it exhibits low toxicity against tumor cells. With the aim of increasing the toxicity of fucan A, silver nanoparticles containing this polysaccharide were synthesized using a green chemistry method. The mean size of these nanoparticles was 210nm. They exhibited a spherical shape and negative surface charge and were stable for 14 months. When incubated with cells, these nanoparticles did not show any toxic effects against various normal cell lines; however, they decreased the viability of various tumor cells, especially renal adenocarcinoma cells 786-0. Flow cytometry analyses showed that the nanoparticles induced cell death responses of 786-0 cells through necrosis. Assays performed with several renal cell lines (HEK, VERO, MDCK) showed that these nanoparticles only induce death of 786-0 cells. The data obtained herein leads to the conclusion that fucan A nanoparticles are promising agents against renal adenocarcinoma.
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| http://dx.doi.org/10.1016/j.ijbiomac.2016.08.043 | DOI Listing |
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