AI Article Synopsis
- Carotid artery stenosis can lead to ischemic stroke, and while a less invasive procedure involving carotid angioplasty and stenting exists, in-stent restenosis poses a challenge for long-term safety and effectiveness.
- This study evaluated the effectiveness of delivering the A20 gene via a modified stent in a pig model to combat in-stent restenosis.
- Results showed that stents releasing the A20 gene significantly improved re-endothelialization and reduced neointimal hyperplasia, suggesting its potential as a promising solution to prevent restenosis-related complications.
Article Abstract
Background: Carotid artery stenosis is a major risk factor for ischemic stroke. Although carotid angioplasty and stenting using an embolic protection device has been introduced as a less invasive carotid revascularization approach, in-stent restenosis limits its long-term efficacy and safety. The objective of this study was to test the anti-restenosis effects of local stent-mediated delivery of the A20 gene in a porcine carotid artery model.
Materials And Methods: The pCDNA3.1EHA20 was firmly attached onto stents that had been collagen coated and treated with N-succinimidyl-3-(2-pyridyldithiol)propionate solution and anti-DNA immunoglobulin fixation. Anti-restenosis effects of modified vs control (the bare-metal stent and pCDNA3.1 void vector) stents were assessed by Western blot and scanning electron microscopy, as well as by morphological and inflammatory reaction analyses.
Results: Stent-delivered A20 gene was locally expressed in porcine carotids in association with significantly greater extent of re-endothelialization at day 14 and of neointimal hyperplasia inhibition at 3 months than stenting without A20 gene expression.
Conclusion: The A20-gene-eluting stent inhibits neointimal hyperplasia while promoting re-endothelialization and therefore constitutes a novel potential alternative to prevent restenosis while minimizing complications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982496 | PMC |
| http://dx.doi.org/10.2147/DDDT.S94984 | DOI Listing |
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