Background: Radiologically isolated syndrome (RIS) is a sub clinical demyelinating neurological disorder and to date no biomarker that triggers the seminal event has been identified. As for multiple sclerosis (MS), disease activity and clinical course are unpredictable. In MS, exploratory studies reported increased IL-17 levels in CSF but results in detecting IL-17 in serum at different stage of the disease are controversial.
Objectives: We investigate levels of IL-17 in serum and CSF in patients diagnosed at different stages of demyelinating diseases (RIS, CIS, relapsing remitting (RR) or active multiple sclerosis patients:AMS) as a marker of inflammatory condition.
Methods: 1417 sera has been tested for IL-17A (1177 from active MS, 80 RRMS, 35 RIS, 35 CIS, 10 IIH: idiopathic intracranial hypertension, and 80 controls) and 240 CSF from RIS, CIS, IIH and controls.
Results: No difference has been found between RIS who early clinically converted and CIS patients who rapidly evolve in McDonald or clinically definite MS, nor active MS. No correlation was found with usual MRI or CSF criteria.
Conclusion: Our results do not confirm that IL-17 can be considerate as a reliable marker of inflammation in the demyelinating spectrum disorders, either in blood or CSF.
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http://dx.doi.org/10.1016/j.jns.2016.07.052 | DOI Listing |
J Neurol
December 2024
Neurology Unit, Department of Translational Medicine, Maggiore Della Carità University Hospital, University of Piemonte Orientale, Corso Mazzini 18, 28100, Novara, Italy.
Background: Cerebrospinal fluid (CSF) kappa-free light chains (KFLC) are becoming a diagnostic biomarker for multiple sclerosis (MS).
Objectives: We aimed to compare the diagnostic performance of intrathecal synthesis biomarkers to that of oligoclonal bands (OB) in diagnosing MS, radiological and clinical isolated syndromes (RIS-CIS) on a large cohort of patients collected over 10 years.
Methods: We collected 1124 patients (58% females) in 10 years who underwent CSF analysis for intrathecal synthesis in the diagnostic work-up, and they were classified according to their diagnosis as 417 MS, 287 with other neurological inflammatory disorders (including 76 RIS-CIS), and 420 non-inflammatory diseases (excluding lymphoproliferative and infective diagnosis).
Am J Otolaryngol
November 2024
Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, New York, USA. Electronic address:
Objective: Radioiodine therapy, commonly used post-thyroidectomy to eliminate residual affected tissue in thyroid cancer patients, can lead to the development of radioiodine induced sialadenitis (RIS). Chronic idiopathic sialadenitis (CIS) is characterized by intermittent and often painful swelling of the salivary glands, not attributed to salivary duct stones. Sialendoscopy is used to treat sialadenitis when conservative management fails.
View Article and Find Full Text PDFOpen Heart
November 2024
Electrophysiology, University of South Florida, Tampa, Florida, USA.
J Neuroimaging
November 2024
Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Background And Purpose: Paramagnetic rim lesions (PRLs) are an MRI biomarker of chronic inflammation in people with multiple sclerosis (MS). PRLs may aid in the diagnosis and prognosis of MS. However, manual identification of PRLs is time-consuming and prone to poor interrater reliability.
View Article and Find Full Text PDFComplement Ther Clin Pract
November 2024
State Key Laboratory of Traditional Chinese Medicine Syndrome/School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China; Intelligent Chinese Medicine Research Institute, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address:
Background: Although acupuncture is widely used to treat ischemic stroke, its effects remain uncertain. This systematic review aims to synthesize current evidence on the effects of acupuncture for ischemic stroke and assess whether current randomized controlled trials (RCTs) have sufficient power to detect its effects.
Methods: Seven databases and two registry platforms were searched systematically from inception to June 13, 2023, to identify RCTs comparing the effects of acupuncture on ischemic stroke with control groups (placebo/blank).
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