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Immune reconstitution inflammatory syndrome in an HIV-infected patient using subcutaneous silicone fillers. | LitMetric

Immune reconstitution inflammatory syndrome in an HIV-infected patient using subcutaneous silicone fillers.

AIDS

aInfectious Diseases Unit, Internal Medicine Department, University Hospital of Ferrol, A Coruña bDermatology Department, University Hospital of Ferrol, A Coruña cHospital Pharmacy, University Hospital of Ferrol, A Coruña dInfectious Diseases and 'Lluita contra la SIDA' Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona eUniversitat Autònoma de Barcelona, Barcelona, Spain.

Published: October 2016

AI Article Synopsis

  • IRIS is a significant issue for HIV-infected patients starting antiretroviral therapy due to their severely weakened immune systems.
  • A case is presented involving a transgender woman with HIV who experienced both tuberculosis-related and silicone-related IRIS after beginning treatment.
  • The authors suggest a link between IRIS and a condition called ASIA, which is triggered by certain immune responses to medical substances.

Article Abstract

The immune reconstitution inflammatory syndrome (IRIS) remains a concern in severely immunosuppressed HIV-infected patients after starting antiretroviral therapy. We present an HIV-infected transgender woman with subcutaneous silicone fillers, who simultaneously developed tuberculosis-associated and silicone-related IRIS. We propose a possible connection between IRIS and the autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

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Source
http://dx.doi.org/10.1097/QAD.0000000000001239DOI Listing

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