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Towards Accurate Biocompatibility: Rethinking Cytotoxicity Evaluation for Biodegradable Magnesium Alloys in Biomedical Applications.
J Funct Biomater
December 2024
CS-Surgical Sciences and Technologies-SS Omics Science Platform for Personalized Orthopedics, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Magnesium and its alloys represent promising candidates for biomedical implants due to their biodegradability and mechanical properties, which are similar to natural bone. However, their rapid degradation process characterized by dynamic pH fluctuations and significant hydrogen gas evolution during biocorrosion adversely affects both in vitro and in vivo assessments. While the ISO 10993-5 and 12 standards provide guidelines for evaluating the in vitro biocompatibility of biodegradable materials, they also introduce testing variability conditions that yield inconsistent results.
View Article and Find Full Text PDFRethinking Biomedical Titanium Alloy Design: A Review of Challenges from Biological and Manufacturing Perspectives.
Adv Healthc Mater
December 2024
School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK.
Current biomedical titanium alloys have been repurposed from other industries, which has contributed to several biologically driven implant failure mechanisms. This review highlights the added value that may be gained by building an appreciation of implant biological responses at the onset of alloy design. Specifically, the fundamental mechanisms associated with immune response, angiogenesis, osseointegration and the potential threat of infection are discussed, including how elemental selection can modulate these pivotal systems.
View Article and Find Full Text PDFUnderstanding carceral mobilities in and through lived experiences of incarceration.
Punishm Soc
December 2024
Carleton University, Canada.
Recent scholarship on carceral mobilities critiques conceptualizations of carceral spaces as fixed and stable, and movements within or around sites of confinement as linear and horizontal. According to this critique, criminological studies of imprisonment have typically embraced what Turner and Peters (2017) ['Rethinking mobility in criminology', 19(1), 96-114] term a 'sedentarist ontology' by failing to consider the complexities of prisoner mobilities in the lived experiences of the carceral. We draw on qualitative interview data from the Prison Transparency Project, a multiyear study initially across four research sites in Canada focused on former prisoners' narratives of their carceral experiences, to identify and analyze the multifaceted mobilities that characterize prison life.
View Article and Find Full Text PDFDigFrag as a digital fragmentation method used for artificial intelligence-based drug design.
Commun Chem
November 2024
State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, Central China Normal University, Wuhan, China.
Fragment-Based Drug Design (FBDD) plays a pivotal role in the field of drug discovery and development. The construction of high-quality fragment libraries is a critical step in FBDD. Conventional fragmentation approaches often rely on rigid rules and chemical intuition, limiting their adaptability to diverse molecular structures.
View Article and Find Full Text PDFRethinking polyiodides: the role of electron-deficient multicenter bonds.
Chem Commun (Camb)
October 2024
Instituto de Diseño para la Fabricación y Producción Automatizada, MALTA Consolider Team, Universitat Politècnica de València, 46022 València, Spain.
Despite a bicentennial history, the interest in polyiodides and related systems still flourishes. The chemical puzzle provided by the intricate nature of chemical bonding in these polyanions remains challenging these days. The advent of the halogen bond and the spreading interest in supramolecular interactions of halogen-based systems promoted further recent interest.
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