Background: The purpose of this study was to clarify cardiovascular structure and function in small for gestational age (SGA) infants across a range of intrauterine growth restriction (IUGR) severity.
Methods and results: This prospective study included 38 SGA infants and 30 appropriate for gestational age (AGA) infants. SGA infants were subclassified into severe and mild SGA according to the degree of IUGR. Cardiovascular structure and function were evaluated using echocardiography at 1 week of age. Compared with the AGA infants, both the severe and mild SGA infants showed increased left ventricular diastolic dimensions (severe SGA 10.2±2.4, mild SGA 8.2±1.3, and AGA 7.3±0.7 mm/kg, P<0.05 for all) and decreased global longitudinal strain (severe -21.1±1.6, mild -22.5±1.8, and AGA -23.8±1.8%, P<0.05 for all). Severe SGA infants showed a decreased mitral annular early diastolic velocity (severe 5.6±1.4 vs. AGA 7.0±1.3 cm/s, P<0.01) and increased isovolumic relaxation time (severe 51.3±9.2 vs. AGA 42.7±8.2 ms, P<0.01). Weight-adjusted aortic intima-media thickness and arterial wall stiffness were significantly greater in both SGA infant groups. These cardiovascular parameters tended to deteriorate with increasing IUGR severity.
Conclusions: SGA infants, including those with mild SGA, showed cardiovascular remodeling and dysfunction, which increased with IUGR severity. (Circ J 2016; 80: 2212-2220).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1253/circj.CJ-16-0352 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes.
Front Endocrinol (Lausanne)
December 2024
Department of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Backgrounds: Many pregnant women suffer from more than one pregnancy complication. However, whether those women experienced a higher risk of adverse birth outcomes is unclear. This study aims to assess the association between the comorbidity of gestational diabetes mellitus (GDM) and hypertension disorders of pregnancy (HDP) and adverse birth outcomes.
View Article and Find Full Text PDFPerinatal outcomes of progesterone in natural frozen-thawed embryo transfer pregnancies: insights from two randomized controlled trials.
Fertil Steril
December 2024
Department of Women's and Children's Health, Uppsala University, 751 85 Uppsala, Sweden; Reproduction Center, Uppsala University Hospital, 751 85 Uppsala, Sweden; Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Objective: To explore whether progesterone supplementation during luteal phase and early pregnancy following a natural frozen-thawed embryo transfer cycle (NC-FET) affects perinatal outcomes.
Design: A secondary data analysis study based on two randomized control trials taking place during 2008-2011 and 2013-2018 at two university hospitals in Sweden.
Subjects: A total of 923 women undergoing a natural FET cycle.
Maternal gestational weight gain and the long-term physical and neurological outcome of small for gestational age children: A 4-year real-world study based on a longitudinal cohort.
Early Hum Dev
December 2024
Department of Pediatrics, Peking University People's Hospital, Beijing, China. Electronic address:
Background: Globally, small for gestational age (SGA) is increasingly prevalent, paralleling the common high-risk pregnancies with inappropriate gestational weight gain (GWG). However, whether maternal GWG was associated with their SGA offspring's long-term development remained unresolved.
Objective: To examine the associations of maternal GWG with the long-term physical and neurological development of SGA children based on a real-world cohort in our hospital.
[Relationship between birth weight and mineral levels in umbilical artery and vein serum].
Wei Sheng Yan Jiu
November 2024
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Objective: To compare the mineral levels in umbilical vein and artery serum and to analyze the relationship between newborn birth weight and the mineral levels in umbilical vein and artery serum by measuring the mineral levels in umbilical vein and artery serum.
Methods: A cross-sectional study was conducted to recruit 101 pairs of maternal and newborn who were hospitalized in Danyang People's Hospital, Jiangsu Province from June to September 2021 as the participants. After delivery, umbilical vein and artery blood were collected, and the levels of manganese(Mn), iron(Fe), cobalt(Co), copper(Cu), zinc(Zn), selenium(Se), magnesium(Mg) and calcium(Ca) in umbilical vein and artery serum were detected by inductively coupled plasma mass spectrum(ICP-MS).
CustOmized versus standard fundal-height measuREments for the detection of small-for-gestational age fetuses in low-risk women (CORE study): A randomized controlled trial.
Int J Gynaecol Obstet
December 2024
BCNatal (Hospital Clinic and Hospital Sant Joan de Deu), Universitat de Barcelona, Barcelona, Spain.
Objective: To compare the proportion of small-for-gestational age (SGA) infants detected by routine care versus a growth assessment protocol using customized fundal-height charts in low-risk pregnancies of a developing country.
Methods: An open label randomized controlled trial was conducted at the Fatima Memorial Hospital (NUR International University, Pakistan). Low-risk pregnant women were randomly allocated to routine care (Mcdonald's rule for fundal height measurements followed by referral for scan with discrepancy of 3 cm from gestational age and a contingency third trimester scan) or the growth assessment protocol (GAP) developed by the Perinatal Institute (UK), which consists of the use of gestation-related optimal weight (GROW) customized charts, alongside management protocols for suspected SGA fetuses, audit tools and training.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!