Cytologic findings following intraoperative use of Floseal hemostatic matrix: A potential diagnostic pitfall in fluid aspiration cytology.

We report the case of a 62-year-old woman who underwent laparoscopic hysterectomy, bilateral salpingo-oophorectomy, and lymph node dissection for endometrial endometrioid carcinoma FIGO grade 1. Cytologic examination of the pelvic washing specimen showed an acellular matrix with frayed edges and cracking artifact. Upon investigation, it became apparent that this could represent hemostatic matrix Floseal that had been used intraoperatively at the lymphadenectomy site. Laboratory replication of the cytologic findings with a Floseal sample confirmed it. This is the first reported case of Floseal in pelvic washing cytology and represents a potential diagnostic pitfall. Diagn. Cytopathol. 2016;44:1117-1119. © 2016 Wiley Periodicals, Inc.