AI Article Synopsis
- - Two new enantiomeric polyketides, (-)-nigrosporaol A and (+)-nigrosporaol A, along with a related compound, (+)-alternarienoic acid, were discovered from three fungal strains.
- - The fungal strains identified were Nigrospora sphaerica, Alternaria alternata, and Phialophora sp.
- - The structures and absolute configurations of these compounds were determined using various methods such as spectroscopy, X-ray diffraction, and the modified Mosher's approach.
Article Abstract
A pair of new enantiomeric polyketides, (-)- and (+)-nigrosporaol A (1a and 1b), along with one related known compound, (+)-alternarienoic acid (2), were isolated from three endolichenic fungal strains, Nigrospora sphaerica (No.83-1-1-2), Alternaria alternata (No.58-8-4-1), and Phialophora sp.(No.96-1-8-1). Their structures, including the absolute configurations, were elucidated on the basis of spectroscopic methods, X-ray diffraction analysis, and the modified Mosher's method.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Daldipyrenones A-C: Caged [6,6,6,6,6] Polyketides Derived from an Endolichenic Fungus 047188.
Org Lett
September 2023
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Daldipyrenones A-C (-), three unprecedented caged xanthone [6,6,6,6,6] polyketides featuring a spiro-azaphilone unit, were discovered from an endolichenic fungus, 047188. The structures of - were determined by using spectroscopic analysis and chemical derivatization. Daldipyrenones are likely derived by combining a chromane biosynthesis intermediate, 1-(2,6-dihydroxyphenyl)but-2-en-2-one, and a spiro-azaphilone, pestafolide A, via radical coupling or Michael addition to form a bicyclo[2.
View Article and Find Full Text PDF(±) Pestalactone D and pestapyrone F, two new isocoumarins from an endolichenic Pestalotiopsis rhododendri.
J Antibiot (Tokyo)
November 2023
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tiantan xili No.1, Beijing, 100050, China.
Three isocoumarins, including two new compounds, (±) pestalactone D (1) and pestapyrone F (2), as well as one known compound, pestapyrone D (3), were isolated from the culture of the endolichenic Pestalotiopsis rhododendri LF-19-12. The planar structures of all compounds were elucidated by NMR and MS spectra. And the absolute configurations of 1 were confirmed by single crystal X-ray diffraction analysis, indicative of it as a racemate of 4S/12S and 4R/12R enantiomers.
View Article and Find Full Text PDFThree new isocoumarin analogues from an endolichenic fungus CPCC 400810.
Nat Prod Res
September 2024
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Article Synopsis
- Five isocoumarin derivatives were isolated from the culture extract of CPCC 400810, including three new compounds named aspermarolides A-C.
- The structures of the compounds were analyzed using spectroscopic techniques, with specific focus on determining double bond geometry and absolute configuration.
- None of the compounds demonstrated cytotoxic effects against the HepG2 and HeLa human cancer cell lines tested.
Influence of light regulation on growth and enzyme production in rare endolichenic fungi.
Folia Microbiol (Praha)
October 2023
School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Selangor Darul Ehsan, 47500, Bandar Sunway, Malaysia.
The influence of light regulation on the growth and enzyme production of three endolichenic fungal isolates, i.e. Pseudopestalotiopsis theae (EF13), Fusarium solani (EF5), and Xylaria venustula (PH22), was determined.
View Article and Find Full Text PDFDiscovery of Pan-peroxisome Proliferator-Activated Receptor Modulators from an Endolichenic Fungus, .
J Nat Prod
December 2022
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Adiponectin-synthesis-promoting compounds possess therapeutic potential to treat diverse metabolic diseases, including obesity and diabetes. Phenotypic screening to find adiponectin-synthesis-promoting compounds was performed using the adipogenesis model of human bone marrow mesenchymal stem cells. The extract of the endolichenic fungus 047215 significantly promoted adiponectin production.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!