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Chronic stress profoundly affects the structure and function of the prefrontal cortex (PFC), a brain region critical for executive functions and emotional regulation. This review synthesizes current knowledge on stress-induced PFC plasticity, encompassing structural, functional, and molecular changes. We examine how chronic stress leads to dendritic atrophy, spine loss, and alterations in neuronal connectivity within the PFC, particularly affecting the medial PFC.
View Article and Find Full Text PDFDorsal bed nucleus of the stria terminalis GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice.
J Psychiatr Res
January 2025
Department of Pediatrics, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China; Jiangxi Provincial Key Laboratory of Trauma, Burn and Pain Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. Electronic address:
Background: Previous studies have shown that neurons in the Bed Nucleus of the Stria Terminalis (BNST) respond to stress and play a key role in mental health. However, the cellular bases of BNST in adolescent depression remain elusive.
Methods: Male C57BL/6 mice were randomly assigned to the control (Ctrl) or chronic unpredictable stress (CUS) groups.
Zebrafish PEX1 Is Required for the Generation of GABAergic Neuron in p3 Domain.
Dev Reprod
December 2024
Department of Chemical and Biological Engineering, Hanbat National University, Daejeon 34158, Korea.
Maintenance of neural progenitors requires Notch signaling in vertebrate development. Previous study has shown that Jagged2-mediated Notch signaling maintains proliferating neural progenitors in the ventral spinal cord. However, components for Jagged-mediated signaling remain poorly defined during late neurogenesis.
View Article and Find Full Text PDFA global overview of shared genetic architecture between smoking behaviors and major depressive disorder in European and East Asian ancestry.
J Affect Disord
January 2025
Department of Environmental Genomics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address:
Background: The co-occurrence of smoking behaviors and major depressive disorder (MDD) has been widely documented in populations. However, the underlying mechanism of this association remains unclear.
Methods: Genome-wide association studies of smoking behaviors and MDD, combined with multi-omics datasets, were usedto characterise genetic correlations, identify shared loci and genes, and explore underlying biological mechanisms.
The role of neuroinflammation in PV interneuron impairments in brain networks; implications for cognitive disorders.
Rev Neurosci
January 2025
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Children's Medical Center Hospital, Dr. Qarib St, Keshavarz Blvd, Tehran 14194, Iran.
Fast spiking parvalbumin (PV) interneuron is an inhibitory gamma-aminobutyric acid (GABA)ergic interneuron diffused in different brain networks, including the cortex and hippocampus. As a key component of brain networks, PV interneurons collaborate in fundamental brain functions such as learning and memory by regulating excitation and inhibition (E/I) balance and generating gamma oscillations. The unique characteristics of PV interneurons, like their high metabolic demands and long branching axons, make them too vulnerable to stressors.
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