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Chronic Inflammation Induced by Escherichia coli Blood Infections as a Risk Factor for Pancreatic Cancer Progression.
Asian Pac J Cancer Prev
December 2024
Iraqi Center for Cancer and Medical Genetic Research, Mustansiriyah University, Baghdad, Iraq.
Background And Aim: Pancreatic cancer exhibits a high level of aggressiveness and is associated with a high mortality rate. The study comprised 50 patients with pancreatic cancer and 50 healthy family members and friends. The main goal is to explore the biomarkers carbohydrate antigen 19-9 (CA19-9), amylase, procalcitonin (PCT), and interleukin 6 (IL-6), confirm the presence of Escherichia coli infection in the patients' bloodstreams, and evaluate the effect of chronic inflammation on the progression of pancreatic cancer.
View Article and Find Full Text PDFLevofloxacin-loaded silicone contact lenses materials for ocular drug delivery.
J Biomater Appl
December 2024
College of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.
Silicone contact lenses (SCL), as an emerging ocular drug delivery system, achieve controlled drug release. However, the existing drug loading methods have limitations such as low drug uptake, complicated operation process, poor welling rate and transmittance of the lens after drug loading. In this study, an effective microemulsion soaking method was proposed to increase the drug-loading capacity of silicone contact lenses.
View Article and Find Full Text PDFFlavonifractor plautii bacteremia following bacterial translocation from the gut: A case report and literature review.
J Infect Chemother
December 2024
Department of Infectious Diseases, Nagoya University Hospital, Aichi, Japan; Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Aichi, Japan.
A 75-year-old male, hospitalized with back pain, remained hospitalized for tests for unexplained colitis, which was diagnosed as inflammatory bowel disease unclassified and treated with antibiotics and prednisolone, resulting in Clostridioides difficile colitis. Therefore, antibiotics were discontinued, and oral metronidazole treatment was initiated; however, as the patient's fever persisted, blood cultures were performed. An anaerobic bottle of blood culture turned positive the following day.
View Article and Find Full Text PDFPerformance of a broth microdilution assay for routine minimum inhibitory concentration determination of 14 anti-tuberculous drugs against the complex based on the EUCAST reference protocol.
Antimicrob Agents Chemother
December 2024
Public Health Agency of Sweden, Solna, Sweden.
This comparative study aimed at qualifying a broth microdilution (BMD) assay for phenotypic drug susceptibility testing (pDST) of complex (MTBC) strains for implementation in a routine DST workflow. The assay was developed based on the EUCAST (European Committee on Antimicrobial Susceptibility Testing) reference protocol for determination of the minimum inhibitory concentration (MIC) of 14 anti-tuberculous drugs (isoniazid [INH], rifampicin [RIF], ethambutol [EMB], amikacin [AMI], moxifloxacin [MFX], levofloxacin [LFX], bedaquiline [BDQ], clofazimine [CFZ], delamanid [DLM], pretomanid [PA], para-aminosalicylic acid [PAS], linezolid [LZD], ethionamide [ETH], and cycloserine [CS]). Forty MTBC strains with various drug resistance profiles were tested to determine the agreement between MIC results and genotypic drug susceptibility testing (gDST) results derived from whole-genome sequencing (WGS).
View Article and Find Full Text PDFDegradation of levofloxacin by dielectric barrier discharge plasma/chlorine process: Roles of reactive species and control of chlorination disinfection byproducts.
J Environ Manage
December 2024
School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, 255000, China. Electronic address:
In this study, a novel process of dielectric barrier discharge (DBD)/chlorine for levofloxacin (LEV) degradation was investigated. The combined system boosted the degradation efficiency of LEV from 77.8% to 97.
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