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Metabolomics insights into the protective molecular mechanism of Vaccinium myrtillus against oxidative stress in intestinal cells.
Sci Rep
March 2025
Department Health Science, University of Basilicata, Viale dell'Ateneo Lucano, 85100, Potenza, Italy.
Blueberry (Vaccinium myrtillus L.) is a rich source of secondary metabolites known for their potent antioxidant, anti-inflammatory, and cytoprotective properties. These compounds are essential in neutralizing reactive oxygen species (ROS), which are implicated in oxidative stress-related diseases.
View Article and Find Full Text PDFAI-Powered Image-Based Assessment of Pressure Injuries Using You Only Look once (YOLO) Version 8 Models.
Adv Wound Care (New Rochelle)
March 2025
Department of Mechanical and Aerospace Engineering, Missouri University of Science and Technology, Rolla, Missouri, USA.
The primary objective of this study is to enhance the detection and staging of pressure injuries using machine learning capabilities for precise image analysis. This study explores the application of the You Only Look Once version 8 (YOLOv8) deep learning model for pressure injury staging. We prepared a high-quality, publicly available dataset to evaluate different variants of YOLOv8 (YOLOv8n, YOLOv8s, YOLOv8m, YOLOv8l, and YOLOv8x) and five optimizers (Adam, AdamW, NAdam, RAdam, and stochastic gradient descent) to determine the most effective configuration.
View Article and Find Full Text PDFIntravenous Vitamin C in Critically Ill Adult Patients With Burns: An Integrative Review.
Nutrition
February 2025
Intensive Care Unit, Department of Critical Care, Hospital de Clínicas (University Hospital), Faculty of Medicine, Universidad de la República, Montevideo, Uruguay.
Early fluid resuscitation may cause fluid overload in seriously ill burn patients, which is associated with losses of micronutrients and poor clinical outcomes. Over the past two to three decades, several animal studies and clinical trials have demonstrated that high-dose intravenous vitamin C may reduce fluid requirements, body weight gain, and wound edema, improving gas exchange and renal function in the acute phase after burn injury. Vitamin C is a scavenger of oxygen free radicals in the endothelium, which can limit the inflammatory response and ischemia-reperfusion injury, promoting wound healing.
View Article and Find Full Text PDFThe Prognostic Role of miR-375 in Head and Neck Squamous Cell Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.
Int J Mol Sci
February 2025
Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy.
Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous group of malignancies with poor survival outcomes, particularly in advanced stages. Identifying prognostic biomarkers could help improve patient management. miR-375, a small non-coding RNA, has been shown to influence tumor growth and immune responses, making it a candidate biomarker.
View Article and Find Full Text PDFImpact of Minimally Manipulated Cell Therapy on Immune Responses in Radiation-Induced Skin Wound Healing.
Int J Mol Sci
February 2025
National Medical Research Radiological Center of the Ministry of Health of Russian Federation, 249036 Obninsk, Russia.
The current treatment of radiation-induced skin wounds utilizes mainly conventional therapies, including topical steroids, creams, ointments, and hydrogel dressings, which do not take into account the immunologic changes that occur in the skin after radiation exposure. Therefore, it is relevant to consider alternative therapies and their impact on changes in the immune landscape of the skin. The aim of this study was to investigate the effect of allogeneic minimally manipulated keratinocytes and fibroblasts on rat skin repair and the development of immune responses.
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