Purpose: This study aimed to compare the sensitivity for detection of brain metastases using postcontrast 3-dimensional, T1W-gradient echo sequence (3DT1W) and maximum intensity projections (MIPs) obtained from the same data set.
Materials And Methods: A prospective analysis of patients with known brain metastases was performed. We compared 1-mm postcontrast 3DT1W with 6-mm MIP reconstructions obtained from the same images (MIP-3DT1) in 95 patients using 1.5 (42 patients) and 3 T (53 patient). Two independent readers analyzed all studies and the examinations were presented in anonymized and random fashion for a total of 190 interpretations per observer. One reader had more than 20 years of experience and the second reader had 1 year of experience.
Results: The least experienced observer found 542 brain metastases on postcontrast non-MIP 3DT1W and 605 with the MIP-3DT1 technique. For this observer, use of MIP resulted in increased number of detected metastases in 36% of patients regardless of field strength. The more experienced observer found 589 brain metastases on non-MIP 3DT1W and 621 with the MIP-3DT1 technique and the use of the latter also resulted in increased detection of metastases in 33% of patients regardless of field strength.
Conclusions: In our study, we found that using MIP-3DT1 reconstructions of previously obtained postcontrast 3DT1W improved detection of brain metastases. This improvement was experienced by both the junior and experienced neuroradiologists and was also better at 3.0 T than at 1.5 T.
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http://dx.doi.org/10.1097/RCT.0000000000000466 | DOI Listing |
Heliyon
January 2025
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Bevacizumab is widely used in various clinical indications, but investigations into its optimal dosage for treating CNS metastases remain limited. The BEEP regimen, comprising bevacizumab, etoposide, and cisplatin, has recently demonstrated promising clinical outcomes for patients with breast cancer brain metastasis (BCBM) or leptomeningeal metastasis (LM). This study aimed to evaluate the exposure-response relationship of bevacizumab in BCBM patients and to explore the improved CNS penetration of chemotherapy by bevacizumab with LM patients.
View Article and Find Full Text PDFCancer Res
January 2025
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Mouse models that faithfully represent the biology of human brain tumors are critical tools for unraveling the underlying tumor biology and screening for potential precision therapies. This is especially true of rare tumor types, many of which have correspondingly few xenograft or cell lines available. Although our understanding of the specific biological pathways driving cancer has improved significantly, identifying the appropriate progenitor populations to drive oncogenic processes represents a significant barrier to efficient mouse model production.
View Article and Find Full Text PDFCancer Res Treat
January 2025
Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University, Seoul, Korea.
Purpose: Ninjury-induced protein 1 (Ninj1) is associated with inflammation and tumor progression and shows increased expression in various cancers. This study aimed to investigate the role of Ninj1 in colitis-associated colorectal cancer (CRC) by focusing on its interaction with 17β-estradiol (E2).
Materials And Methods: Using an azoxymethane (AOM)/dextran sodium sulfate (DSS) mouse model of colitis-associated CRC, wild-type (WT) and Ninj1 knockout (KO) male mice were treated with or without E2.
J Nanobiotechnology
January 2025
Department of Pharmacy The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Glioblastoma multiforme (GBM) is characterized by pronounced immune escape and resistance to chemotherapy-induced apoptosis. Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM. Notably, cisplatin (CDDP) demonstrated a capacity of inducing pyroptosis by activating caspase-3 to cleave GSDME, coupled with the release of proinflammatory factors, indicating the potential as a viable approach of inducing anti-tumor immune activation.
View Article and Find Full Text PDFNeurosurg Rev
January 2025
Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, 113-8655, Japan.
Recent technologic advancements have facilitated the use of hypofractionated Gamma Knife-based radiosurgery (HF-GKRS) to treat large lesions or those in eloquent areas. This study aimed to analyze the preliminary results of HF-GKRS for these meningiomas, and to determine its effectiveness and safety. This single-center retrospective study analyzed data of patients who underwent HF-GKRS for large meningiomas or those in eloquent areas with > 6 months of follow-up.
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