Naturally occurring homoisoflavonoids containing either 5,7-dihydroxy-6-methoxy or 7-hydroxy-5,6-dimethoxy groups such as the antiangiogenic homoisoflavanone, cremastranone, were synthesized via three or four linear steps from the known 4-chromenone. This facile synthesis includes chemoselective 1,4-reduction of 4-chromenone and selective deprotection of 3-benzylidene-4-chromanone a containing C7-benzyloxy group.
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School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
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Department of Food Science and Nutrition, Kimchi Research Institute, Pusan National University, Busan 46241, Republic of Korea.
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January 2025
School of Traditional Chinese Medicine, Jiangsu Medical College, Yancheng, Jiangsu, China.
Article Synopsis
- Methylophiopogonanone A (MOA) is a compound found in Ophiopogon japonicus known for its pharmacological effects; this study aimed to develop a method to measure MOA levels in rat plasma.
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Department of Food Science and Nutrition, Pusan National University, Busan 46241, Republic of Korea.
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