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Exposure to Rifampicin and its Metabolite 25-Deacetylrifampicin Rapidly Decreases During Tuberculosis Therapy.
Clin Pharmacokinet
January 2025
Facultés de Médecine et de Pharmacie de Lyon, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Background And Objective: Limited information is available on the pharmacokinetics of rifampicin (RIF) along with that of its active metabolite, 25-deacetylrifampicin (25-dRIF). This study aimed to analyse the pharmacokinetic data of RIF and 25-dRIF collected in adult patients treated for tuberculosis.
Methods: In adult patients receiving 10 mg/kg of RIF as part of a standard regimen for drug-susceptible pulmonary tuberculosis enrolled in the Opti-4TB study, plasma RIF and 25-dRIF concentrations were measured at various occasions.
Introduction: Niacin is a non-statin lipid-lowering therapy that has been shown to lower triglycerides and improve other risk factors for renal outcomes. Despite these favorable data, the effect of niacin on long-term kidney outcomes remains unclear. The aim of this study is to examine the associations of niacin therapies with incident chronic kidney disease (CKD), end-stage renal disease (ESRD), and death in patients with estimated glomerular filtration (eGFR) of at least 60 mL/min/1.
View Article and Find Full Text PDFIntegrated analysis of marked and count data to characterize fine-scale stream fish movement.
Oecologia
January 2025
Department of Fish, Wildlife, and Conservation Biology, Colorado State University, Fort Collins, CO, 80523, USA.
Immigration and emigration are key demographic processes of animal population dynamics. However, we have limited knowledge on how fine-scale movement varies over space and time. We developed a Bayesian integrated population model using individual mark-recapture and count data to characterize fine-scale movement of stream fish at 20-m resolution in a 740-m study area every two months for 28 months.
View Article and Find Full Text PDFPoor Outcome of Rare Lactobacillus Bacteremia and Endocarditis in a Patient With Frequent Consumption of Live Culture Yogurts.
J Community Hosp Intern Med Perspect
January 2025
Division of Infectious Disease, Department of Internal Medicine, Naples Comprehensive Health, Naples, FL, USA.
is a gram-positive bacterium commonly found in dairy products and used as a probiotic due to its resistance to acid and bile. While generally considered safe, rare cases of bacteremia and endocarditis have been reported, primarily in individuals with significant risk factors. This report discusses an elderly male with a history of cardiovascular diseases, diabetes, and asthma, who developed bacteremia and endocarditis after consuming large quantities of Greek yogurt.
View Article and Find Full Text PDFNeurocognitive Markers during Maximum Alcohol Use in Late Adolescence as Predictors of Change in Later Drinking Behaviors.
Mental Health Sci
September 2024
Department of Psychiatry, UC San Diego, La Jolla, CA, USA.
Background: The influence of alcohol use on later neurocognitive functioning is well researched, yet few studies have investigated whether neurocognition post-drinking initiation in adolescence predicts changes in later alcohol use.
Objective: Investigate neurocognitive task performance during maximum alcohol use in late adolescence as predictors of drinking behaviors 3-7 years later.
Methods: Analyses () were conducted on a longitudinal dataset involving adolescents (12-13 years-old) who were followed for 16 years.
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