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Toll-tally tubular: A newly identified Toll-like receptor-FoxO pathway regulates dynamics of the neuronal microtubule network. | LitMetric
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Toll-tally tubular: A newly identified Toll-like receptor-FoxO pathway regulates dynamics of the neuronal microtubule network.

Kate O'Connor-Giles

J Cell Biol

Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706

Published: August 2016

Recent studies reveal a conserved role for FoxO transcription factors in establishing neuronal structure and circuit function. In this issue, McLaughlin et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601014) identify a novel Toll-like receptor-FoxO pathway that represses the mitotic kinesin Pavarotti/MKLP1 to promote dynamic microtubules required for axonal transport and activity-dependent remodeling of presynaptic terminals.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987299PMC
http://dx.doi.org/10.1083/jcb.201607118DOI Listing

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