Endoplasmic reticulum (ER)-mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2b at ER-mitochondria contact sites, thereby affecting ER-mitochondrial calcium transfer and mitochondrial bioenergetics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987300 | PMC |
| http://dx.doi.org/10.1083/jcb.201607124 | DOI Listing |
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