AI Article Synopsis
- Four products from the breakdown of bilirubin were isolated and characterized, identified as constitutional isomers of propentdyopents (PDPs).
- These PDPs can further transform into biologically active compounds known as bilirubin oxidation end products (Z-BOXes).
- The presence of PDPs was confirmed in human bile and gallstones, suggesting they might play a role in conditions like cerebral vasospasms and liver dysfunction.
Article Abstract
Four endogenous products of oxidative bilirubin degradation were isolated and fully characterized. The constitutional isomers belong to the propentdyopents (PDPs). Their structures and further oxidative transformations to biologically active bilirubin oxidation end products (Z-BOXes) are reported. Using liquid chromatography-mass spectrometry protocols, PDPs were detected in human bile and gallstones. Given the recent interest in BOXes as effectors in cerebral vasospasms and liver dysfunction, co-occurring PDPs represent an additional potentially active compound class to be considered.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.6b02287 | DOI Listing |
Publication Analysis
Top Keywords
oxidative bilirubin
8
bilirubin degradation
8
isolation identification
4
identification intermediates
4
intermediates oxidative
4
degradation endogenous
4
endogenous products
4
products oxidative
4
degradation isolated
4
isolated fully
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!