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Medical conditions of Omer Seyfettin (1884-1920), the father of Turkish short stories, enshrined as a mystery.
J Med Biogr
May 2022
Department of Medical History and Ethics, School of Medicine, Erciyes University, Kayseri, Turkey.
Born in 1884 in Balıkesir, Turkey, Ömer Seyfettin was a leading figure among modern Turkish short story writers whose death in 1920 at the age of 36 led to long-term speculations about his fatal illness. In order to pay homage to his memory in the centennial of his death and to shed light on his later medical condition, this paper seeks to reexamine his last days from a medico-historical perspective. Our findings indicate that there was a notable decline in his health occurring after 1917 when he was confined to social isolation.
View Article and Find Full Text PDFCellular stress and AMPK links metformin and diverse compounds with accelerated emergence from anesthesia and potential recovery from disorders of consciousness.
Med Hypotheses
March 2019
Finley BioSciences, Houston, TX 77042-4539, United States. Electronic address:
The neural correlates of consciousness and the mechanisms by which general anesthesia (GA) modulate such correlates to induce loss of consciousness (LOC) has been described as one of the biggest mysteries of modern medicine. Several cellular targets and neural circuits have been identified that play a critical role in LOC induced by GA, including the GABAA receptor and ascending arousal nuclei located in the basal forebrain, hypothalamus, and brain stem. General anesthetics (GAs) including propofol and inhalational agents induce LOC in part by potentiating chloride influx through the GABAA receptor, leading to neural inhibition and LOC.
View Article and Find Full Text PDFThe pathophysiology of emergence delirium (ED) remains a mystery. Using a case study approach, ED is discussed from a clinical perspective. The case is a 4-year-old male who had myringotomy tube placement while anesthetized with sevoflurane.
View Article and Find Full Text PDFCatatonia, Delirium, and Critical Illness: A Diagnostic Statistical Manual 5 Mystery Partially Disentangled.
Crit Care Med
November 2017
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Psychology, Maastricht University Medical Centre (MUMC+), Maastricht; Mutsaersstichting Venlo; and Division of Adult Psychiatry, Department of Psychiatry and Psychology, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands Division of Child and Adolescent Psychiatry; and Division of Adult Psychiatry, Department of Psychiatry and Psychology, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands.
The Mystery of Delirium. Could Biomarkers of Endothelial Activation Reveal the Secrets?
Crit Care Med
September 2016
Department of Anesthesiology, Perioperative, Critical Care, and Pain Medicine Brigham and Women's Hospital Harvard Medical School Boston, MA.
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