Diabetic retinopathy, a common and sight-threatening microvascular complication of diabetes mellitus, is a leading cause of blindness among working-aged adults. Medical therapies including intensive control of hyperglycemia and hypertension have been shown to reduce the incidence and progression of diabetic retinopathy. The association of dyslipidemia and treatment with statins with diabetic retinopathy is inconsistent in epidemiologic studies. However, two recent randomized clinical trials have demonstrated beneficial effects of systemic fenofibrate therapy in reducing the progression of diabetic retinopathy independently of serum lipid levels. These findings suggest that fenofibrate may be an effective strategy for reducing the progression of diabetic retinopathy, thus reducing the large and growing public health burden of treating the sight-threatening complications of diabetic retinopathy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323449 | PMC |
| http://dx.doi.org/10.1007/s11892-016-0786-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Benefits of Cilostazol's Effect on Vascular and Neuropathic Complications Caused by Diabetes.
Med Sci (Basel)
December 2024
Department of Molecular Pathobiology, New York University, New York, NY 10010, USA.
Diabetes mellitus (DM) is a global health concern with a rising incidence, particularly in aging populations and those with a genetic predisposition. Over time, DM contributes to various complications, including nephropathy, retinopathy, peripheral arterial disease (PAD), and neuropathy. Among these, diabetic neuropathy and PAD stand out due to their high prevalence and significant impact on patients' quality of life.
View Article and Find Full Text PDFDownregulation of MerTK in circulating T cells of patients with non-proliferative diabetic retinopathy.
Front Endocrinol (Lausanne)
January 2025
Department of Ophthalmology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Objective: To explore the differential gene expression in peripheral blood immune cells of individuals with type 2 diabetes mellitus (DM), comparing those with and without non-proliferative diabetic retinopathy (NPDR).
Methods: From a pool of 126 potential participants, 60 were selected for detailed analysis. This group included 12 healthy donors (HDs), 22 individuals with DM, and 26 with NPDR.
Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications.
Front Med (Lausanne)
January 2025
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
The growing global prevalence of diabetes mellitus (DM), along with its associated complications, continues to rise. When clinically detected most DM complications are irreversible. It is therefore crucial to detect and address these complications early and systematically in order to improve patient care and outcomes.
View Article and Find Full Text PDFCross-cutting effect of type 2 diabetes on the sensorimotor control of balance.
Front Clin Diabetes Healthc
January 2025
Department of Human Movement Science, Oakland University, Rochester, MI, United States.
Type 2 Diabetes is a highly prevalent chronic disorder that affects multiple systems through microvascular complications. Complications such as diabetic peripheral neuropathy, diabetic retinopathy, and diabetic vestibular dysfunction (vestibulopathy) all directly interfere with the sensory components of balance and postural stability. The resulting impairments cause increased falls risk and instability, making it difficult to perform daily task or exercise.
View Article and Find Full Text PDFMeta-Analysis of the Association Between -2578C/A Polymorphism and Susceptibility to Type 2 Diabetic Retinopathy.
Curr Eye Res
January 2025
Fundus Disease Department, Ai'er Ophthalmology Hospital of Shangrao, Shangrao, Jiangxi, China.
Purpose: to investigate the association between vascular endothelial growth factor (-2578C/A polymorphism and susceptibility to type 2 diabetic retinopathy (T2DR) by meta-analysis.
Methods: According to the search strategy, Four databases were retrieved to identify the literature on the relationship between polymorphism and the risk of T2DR from inception to July 2024. Stata 15.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!