AI Article Synopsis
- Nine new phenanthrenes and a new benzyl glycoside were identified from Bletilla formosana, alongside 45 known compounds.
- The structures of these new compounds were determined using 1D and 2D NMR spectroscopy.
- The isolated compounds showed promising anti-inflammatory activity, with varying IC50 values, indicating that phenanthrenes were the most potent inhibitors compared to other types.
Article Abstract
Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.
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| http://dx.doi.org/10.1021/acs.jnatprod.6b00118 | DOI Listing |
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