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Intrauterine adhesions are growths of fibrotic tissue within the uterine cavity and can arise from a variety of tissue-damaging stimuli. Immune cells are known to mediate fibrotic responses, but specific mechanisms require further elucidation. Here, we compared intrauterine fibrosis development and immune responses across different mouse strains and induction methods.
View Article and Find Full Text PDFHepatoprotective and neuroprotective effects of quinacrine against bile duct ligation-induced hepatic encephalopathy in rats: Role of bone morphogenetic proteins signaling.
Life Sci
December 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:
Article Synopsis
- The study evaluated quinacrine, an FDA-approved drug, for its protective effects against hepatic encephalopathy (HE) in a rat model with bile duct ligation (BDL) and focused on the liver-brain communication through BMP2 signaling.
- Results indicated that BDL caused significant liver damage and cognitive deficits in rats, but quinacrine treatment improved liver function and cognitive abilities by restoring crucial signaling pathways.
- The findings suggest that quinacrine may offer potential benefits for treating HE by enhancing liver and brain health, highlighting the role of BMP2 signaling in this process.*
Cardio- and Vasoprotective Effects of Quinacrine in an In Vivo Rat Model of Myocardial Ischemia/Reperfusion Injury.
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June 2024
Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
This study aimed to investigate the cardioprotective effect of quinacrine in an in vivo model of myocardial ischemia/reperfusion injury. A 30-min regional myocardial ischemia followed by a 2-h reperfusion was modeled in anesthetized Wistar rats. Starting at the last minute of ischemia and during the first 9 min of reperfusion the rats in the control (n=8) and experimental (n=9) groups were injected with 0.
View Article and Find Full Text PDFAI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data.
Brief Bioinform
March 2024
Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, 23955, Saudi Arabia.
Cancer stem cells (CSCs) are a subpopulation of cancer cells within tumors that exhibit stem-like properties and represent a potentially effective therapeutic target toward long-term remission by means of differentiation induction. By leveraging an artificial intelligence approach solely based on transcriptomics data, this study scored a large library of small molecules based on their predicted ability to induce differentiation in stem-like cells. In particular, a deep neural network model was trained using publicly available single-cell RNA-Seq data obtained from untreated human-induced pluripotent stem cells at various differentiation stages and subsequently utilized to screen drug-induced gene expression profiles from the Library of Integrated Network-based Cellular Signatures (LINCS) database.
View Article and Find Full Text PDFPromising effects of 1,8 Cineole to control Giardia lamblia infection: Targeting the inflammation, oxidative stress, and infectivity.
Acta Trop
July 2024
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address:
Reportedly, synthetic drugs such as metronidazole, furazolidone, tinidazole, and quinacrine are used for the treatment of giardiasis but are associated with adverse effects. In this study, we aimed to investigate the in vitro and in vivo effects of eucalyptol (ECT, 1,8 cineole) alone and in combination with metronidazole (MNZ) on Giardia lamblia. The effects of ECT on cell viability, plasma membrane permeability, and gene expression levels of adenylate cyclase (AK) and extracellular signal kinases 1 and 2 (ERK1 and ERK2) in trophozoites of G.
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